IL23A
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Official Full Name
interleukin 23, alpha subunit p19
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Overview
Interleukin-23 (IL-23) is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit). IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. In conjunction with IL-6 and TGF-β1, IL-23 stimulates naive CD4+ T cells to differentiate into a novel subset of cells called Th17 cells, which are distinct from the classical Th1 and Th2 cells. Th17 cells produce IL-17, a proinflammatory cytokine that enhances T cell priming and stimulates the production of proinflammatory molecules such as IL-1, IL-6, TNF-alpha, NOS-2, and chemokines resulting in inflammation. Knockout mice deficient in either p40 or p19, or in either subunit of the IL-23 receptor (IL-23R and IL12R-β1) develop less severe symptoms of multiple sclerosis and inflammatory bowel disease highlighting the importance of IL-23 in the inflammatory pathway. -
Synonyms
IL23A; interleukin 23, alpha subunit p19; P19; SGRF; IL-23; IL-23A; IL23P19; MGC79388; interleukin-23 subunit alpha; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Cynomolgus Monkey
- Guinea pig
- Human
- Marmoset
- Mouse
- Pig
- Rat
- Rhesus Macaque
- CHO
- E.coli
- HEK293
- HEK293F
- HEK293T
- Hi-5 Insect Cell
- Human Cell
- Human cells
- In Vitro Cell Free System
- In vitro E. coli expression system
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Sf9
- Spodoptera Frugiperda
- Wheat Germ
- Yeast
- C
- Fc
- His
- Flag
- GST
- His (Fc)
- Avi
- Myc
- His(N
- ter)
- His|Avi
- His|SUMO
- SUMO
- DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- IL23A Related Articles
- IL23A Related Research Area
IL23A involved in several pathways and played different roles in them. We selected most pathways IL23A participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL23A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | XCL2;CXCR4B;CCL6;IL12RB2;IFNA2;CCL3L1;CCR9;TNFRSF11B;IL11RA |
Jak-STAT signaling pathway | PTPN2B;LEP;SOCS5;FHL1A;PIK3CB;CISH;AOX4;CRFB4;MPL |
Pertussis | GNAI2;ITGB2;MAPK12;C4BPB;C1R;IL12B;Casp3;RHOA;TNF |
Tuberculosis | MAPK1;RFXAP;CD14;IFNA12;TLR9;PPP3CA;RFX5;AKT1;CAMK2D |
Inflammatory bowel disease (IBD) | TNF;IFNGR1;HLA-DQB1;IFNG;IL5;HLA-DQA1;IL18;TGFB3;RORA |
Rheumatoid arthritis | ATP6V1C2;CD86;GM-CSF;TLR2;TNFSF13;ATP6V0D2;TGFB1;IL11;ATP6V1G1 |
IL23A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by IL23A itself. We selected most functions IL23A had, and list some proteins which have the same functions with IL23A. You can find most of the proteins on our site.
Function | Related Protein |
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IL23A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL23A here. Most of them are supplied by our site. Hope this information will be useful for your research of IL23A.
- Q&As
- Reviews
Q&As (6)
Ask a questionPlease inquiry our product manager with specific product.
Yes, drugs like ustekinumab and risankizumab, which target IL23A, have been approved for certain autoimmune diseases.
IL23A primarily plays a role in regulating the adaptive immune response.
IL23A is associated with the inflammation of the spine and joints seen in ankylosing spondylitis, making it a target for therapeutic intervention.
In rheumatoid arthritis, IL23A is involved in the dysregulation of the immune system, leading to joint inflammation and damage.
IL23A is implicated in the pathogenesis of Crohn's disease, contributing to chronic inflammation in the gastrointestinal tract.
Customer Reviews (3)
Write a reviewCoupled with the manufacturer's exceptional technical support and commitment to customer satisfaction, researchers can confidently utilize the IL23A protein in their studies, knowing that they have the necessary resources and assistance to succeed.
Its remarkable attributes and consistent results make it an indispensable tool in various experimental applications.
Highly recommended for its exceptional performance in ELISA, the IL23A protein is a top contender for researchers involved in protein electron microscopy structure analysis.
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