Recombinant Rat Bmp4 protein, His/S-tagged

• Cat.No.: Bmp4-215R
• Product Overview: Recombinant Rat Bmp4 fused with His/S tag was expressed in E. coli.

Specification

• Description: Human BMP-4 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor ß (TGF-ß) superfamily. BMPs were originally identified as protein regulators of cartilage and bone formation. However, they havesince been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. BMP-4 is synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
• Source: E. coli
• Species: Rat
• Tag: His/S
• Form: Lyophilized from sterile PBS, pH 7.4
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Store at -70 centigrade. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: Bmp4 bone morphogenetic protein 4 [ Rattus norvegicus ]
• Official Symbol: Bmp4
• Synonyms: BMP4; bone morphogenetic protein 4; BMP-4; BMP-2B; bone morphogenetic protein 2B; BOMPR4A
• Gene ID: 25296
• mRNA Refseq: NM_012827
• Protein Refseq: NP_036959
• Chromosome Location: 15p14
• Pathway: Adipogenesis, organism-specific biosystem; Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem; Pathways in cancer, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem
• Function: BMP receptor binding; BMP receptor binding; chemoattractant activity; chemoattractant activity; cytokine activity; cytokine activity; growth factor activity; heparin binding; heparin binding; protein homodimerization activity

Reviews

11/22/2020

The BMP4 protein is a valuable resource for researchers due to its high quality and its ability to meet specific experimental needs.

08/26/2020

the manufacturer's technical support team can offer prompt assistance in case any issues arise during the handling or application of the BMP4 protein.

06/05/2018

The manufacturer's support can play a crucial role in assisting researchers throughout their trials.

Q&As

How is BMP4 applied in spinal fusion surgery?

BMP4 can be used in spinal fusion surgery to stimulate bone growth and fuse vertebrae together, which can alleviate back pain and stabilize the spine.

Are there any genetic disorders related to BMP4?

Mutations in BMP4 or its receptors can lead to congenital disorders, such as orofacial clefts and heart defects.

Are there ongoing clinical trials involving BMP4 in regenerative medicine?

Yes, there are ongoing trials exploring the use of BMP4 in regenerative medicine for conditions like osteoarthritis and tendon injuries.

Are there any potential risks or side effects associated with the clinical use of BMP4?

Yes, some risks include excessive bone growth, swelling, and inflammation at the application site. These complications can be carefully managed by healthcare providers.

Can BMP4 be used in cosmetic surgery?

Yes, BMP4 can be used to aid in tissue regeneration in cosmetic procedures, such as in the reconstruction of facial bone defects or enhancement of soft tissue volume.