Active Recombinant Cynomolgus IL-8 protein, His-tagged

• Cat.No.: IL-8-1023C
• Product Overview: Recombinant Cynomolgus IL-8 protein(Ala 23 - Pro 101), fused to His tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Cynomolgus
• Tag: His
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4.
• Bio-activity: Immobilized Cynomolgus IL-8, His Tag at 1 μg/mL (100 μL/well) can bind Monoclonal Anti-Human IL-8 Antibody, Human IgG1 with a linear range of 0.1-2 ng/mL.
• Molecular Mass: 11.0 kDa
• Protein length: Ala 23 - Pro 101
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: This product is stable after storage at:
  -20°C to -70°C for 12 months in lyophilized state;
  -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Reviews

06/24/2022

Good stability in vivo.

04/14/2020

Can enhance the effectiveness of the body's immune response.

12/26/2019

It has high biological activity and stability.

Q&As

How relationship between IL-8 and inflammatory response?

It is a pro-inflammatory factor, which can promote neutrophils' chemotaxis and adhesion to inflammatory sites, thus participating in the inflammatory response process.

What is the inflammatory response mechanism of IL-8?

IL-8 promotes chemotaxis and adhesion of neutrophils to inflammatory sites by acting on CXCR1 and CXCR2 receptors on the surface of neutrophils.

Through which signaling pathways does IL-8 function?

Plays its role mainly through JNK, ERK, p38 and NF-κB signaling pathways.

What is the relationship between IL-8 and other cytokines?

The relationship between IL-8 and other cytokines is complex, and it may interact with IL-6, TNF-α and other cytokines in inflammatory response.

Are there have any clinical applications of IL-8?

Recombinant IL-8 protein can be used to treat certain inflammatory diseases. For example, it can be used to treat asthma, chronic obstructive pulmonary disease, and so on.

Which application prospect of IL-8 in lung cancer treatment?

It may have a certain application prospect in the treatment of lung cancer, which can be treated by regulating tumor microenvironment and promoting immune response.