Active Recombinant Full Length Human DAXX Protein, C-Flag-tagged
Cat.No. : | DAXX-335HFL |
Product Overview : | Recombinant Full Length Human DAXX Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Bio-activity : | Pull-down assay |
Molecular Mass : | 81.2 kDa |
AA Sequence : | MATANSIIVLDDDDEDEAAAQPGPS HPLPNAASPGAEAPSSSEPHGARGS SSSGGKKCYKLENEKLFEEF LELCKMQTADHPEVVPFLYNRQQRA HSLFLASAEFCNILSRVLSRARSRP AKLYVYINELCTVLKAHSAK KKLNLAPAATTSNEPSGNNPPTHLS LDPTNAENTASQSPRTRGSRRQIQR LEQLLALYVAEIRRLQEKEL DLSELDDPDSAYLQEARLKRKLIRL FGRLCELKDCSSLTGRVIEQRIPYR GTRYPEVNRRIERLINKPGP DTFPDYGDVLRAVEKAAARHSLGLP RQQLQLMAQDAFRDVGIRLQERRHL DLIYNFGCHLTDDYRPGVDP ALSDPVLARRLRENRSLAMSRLDEV ISKYAMLQDKSEEGERKKRRARLQG TSSHSADTPEASLDSGEGPS GMASQGCPSASRAETDDEDDEESDE EEEEEEEEEEEEATDSEEEEDLEQM QEGQEDDEEEDEEEEAAAGK DGDKSPMSSLQISNEKNLEPGKQIS RSSGEQQNKGRIVSPSLLSEEPLAP SSIDAESNGEQPEELTLEEE SPVSQLFELEIEALPLDTPSSVETD ISSSRKQSEEPFTTVLENGAGMVSS TSFNGGVSPHNWGDSGPPCK KSRKEKKQTGSGPLGNSYVERQRSV HEKNGKKICTLPSPPSPLASLAPVA DSSTRVDSPSHGLVTSSLCI PSPARLSQTPHSQPPRPGTCKTSVA TQCDPEEIIVLSDSDTRTRPLEQKL ISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
Protein Pathways : | Amyotrophic lateral sclerosis (ALS), MAPK signaling pathway |
Gene Name : | DAXX death domain associated protein [ Homo sapiens (human) ] |
Official Symbol : | DAXX |
Synonyms : | DAP6; EAP1; BING2; SMIM40 |
Gene ID : | 1616 |
mRNA Refseq : | NM_001141969.2 |
Protein Refseq : | NP_001135441.1 |
MIM : | 603186 |
UniProt ID : | Q9UER7 |
Products Types
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DAXX-717H | Recombinant Human DAXX Protein, His (Fc)-Avi-tagged | +Inquiry |
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DAXX-2205M | Recombinant Mouse DAXX Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
DAXX-7071HCL | Recombinant Human DAXX 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDAXX protein interacts with a wide range of cellular proteins, including transcription factors, histones, and chromatin remodeling complexes, which has implications for its clinical relevance in various cellular processes.
Targeting DAXX protein may have therapeutic implications in cancer treatment, as well as in aging-related diseases and neurodegenerative disorders, by modulating its functions and interactions with other cellular proteins.
Studies have suggested that DAXX protein may have implications in aging-related diseases, particularly in relation to telomere dysfunction and cellular senescence.
DAXX protein has been implicated in neurodegenerative diseases through its involvement in cellular stress responses and protein aggregation, which are hallmarks of diseases such as Alzheimer's and Parkinson's.
DAXX protein has been identified as a potential therapeutic target for cancer treatment due to its involvement in regulating the activity of key oncogenes and tumor suppressor genes.
Customer Reviews (3)
Write a reviewIts ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.
The DAXX protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.
the DAXX protein has proven to be invaluable in protein electron microscopy structure analysis.
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