Active Recombinant Full Length Human LOX Protein, C-Flag-tagged

• Cat.No.: LOX-213HFL
• Product Overview: Recombinant Full Length Human LOX Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Enzyme activity
  In vivo treatment
  Cell treatment
  Binding assay
  In vivo treatment
• Molecular Mass: 46.8 kDa
• AA Sequence: MRFAWTVLLLGPLQLCALVHCAPPA AGQQQPPREPPAAPGAWRQQIQWEN NGQVFSLLSLGSQYQPQRRR DPGAAVPGAANASAQQPRTPILLIR DNRTAAARTRTAGSSGVTAGRPRPT ARHWFQAGYSTSRAREAGAS RAENQTAPGEVPALSNLRPPSRVDG MVGDDPYNPYKYSDDNPYYNYYDTY ERPRPGGRYRPGYGTGYFQY GLPDLVADPYYIQASTYVQKMSMYN LRCAAEENCLASTAYRADVRDYDHR VLLRFPQRVKNQGTSDFLPS RPRYSWEWHSCHQHYHSMDEFSHYD LLDANTQRRVAEGHKASFCLEDTSC DYGYHRRFACTAHTQGLSPG CYDTYGADIDCQWIDITDVKPGNYI LKVSVNPSYLVPESDYTNNVVRCDI RYTGHHAYASGCTISPYTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein

Gene Information

• Gene Name: LOX lysyl oxidase [ Homo sapiens (human) ]
• Official Symbol: LOX
• Synonyms: AAT10
• Gene ID: 4015
• mRNA Refseq: NM_002317.7
• Protein Refseq: NP_002308.2
• MIM: 153455
• UniProt ID: P28300