Active Recombinant Human ACE2 Protein, His-tagged, Alexa Fluor® 647 conjugated
Cat.No. : | ACE-32H |
Product Overview : | Recombinant Human Alexa Fluor® 647 ACE-2 (Gln18-Ser740) protein with a C-terminal 10-His tag was expressed in Mammalian Cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. |
Source : | Mammalian Cells |
Species : | Human |
Tag : | His |
Form : | Recombinant Human ACE2 is prone to proteolytic cleavage at C-terminus. The predominant form of the purified protein lacks the His tag. Labeled with Alexa Fluor® 647 Excitation Wavelength: 650 nm Emission Wavelength: 668 nm |
Bio-activity : | Measured by flow cytometry for its ability to bind Biotinylated Recombinant SARS-CoV-2 Spike RBD Fc Chimera Avi-tag conjugated streptavidin beads at 0.37-3.33 μg/mL (100 μL/well). |
Molecular Mass : | 85 kDa |
N-terminal Sequence Analysis : | No results obtained: Gln18 predicted |
Endotoxin : | < 1.0 EU/ μg of the protein by the LAL method. |
Purity : | > 90% by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Protect from light. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after opening. 3 months, -20 to -70 centigrade under sterile conditions after opening. |
Storage Buffer : | Supplied as a 0.2 μm filtered solution in Tris, NaCl, ZnCl2 and Glycerol with BSA as a carrier protein. |
Shipping : | The product is shipped with dry ice or equivalent. |
Gene Name : | ACE2 angiotensin converting enzyme 2 [ Homo sapiens (human) ] |
Official Symbol : | ACE2 angiotensin converting enzyme 2 [ Homo sapiens (human) ] |
Synonyms : | ACE2; angiotensin converting enzyme 2; ACEH; angiotensin-converting enzyme 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme homolog; angiotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; truncated angiotensin converting enzyme 2; EC 3.4.17.23 |
Gene ID : | 59272 |
mRNA Refseq : | NM_021804 |
Protein Refseq : | NP_068576 |
MIM : | 300335 |
UniProt ID : | Q9BYF1 |
Products Types
◆ Recombinant Protein | ||
ACE-104R | Recombinant Rat ACE Protein, His (Fc)-Avi-tagged | +Inquiry |
ACE-025H | Recombinant Human ACE Protein, C-His-tagged | +Inquiry |
ACE-011H | Active Recombinant Human ACE Protein, His-tagged | +Inquiry |
ACE-31R | Recombinant Rabbit ACE Protein, His-tagged | +Inquiry |
ACE-2412H | Recombinant Human ACE Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
ACE-3047R | Native rabbit ACE | +Inquiry |
◆ Lysates | ||
ACE-9094HCL | Recombinant Human ACE 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2409 | Angiotensin II Converting Enzyme (ACE2) Inhibitor Screening Kit | +Inquiry |
Kit-2408 | Angiotensin I Converting Enzyme (ACE1) Inhibitor Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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