Active Recombinant Human Activin B
Cat.No. : | Activin B-59H |
Product Overview : | The human prepro-Activin βA chain (amino acid residues 1 - 310) was fused to the human mature Activin βB chain (Mason, A.J. et al., 1986, Biochem. Biophys. Res. Comm. 135:957 - 964). The chimeric protein was expressed in CHO cells. |
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Description : | Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction.Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian beta A, beta B, beta C, beta E and Xenopus beta D) have been cloned to date. The activin/inhibin nomenclature reflects the subunit composition of the proteins: Activin A (beta A - beta A), Activin B (beta B - beta B), Activin AB (beta A - beta B), Inhibin A (alpha - beta A) and Inhibin B (alpha - beta B). |
Source : | CHO cells |
Species : | Human |
Bio-activity : | Measured by its ability to induce hemoglobin expression in K562 cells (Schwall, R.H. et al., 1991, Method Enzymol. 198:340). |
Molecular Mass : | Recombinant human mature Activin B is a disulfide-linked homodimer of two βB subunits. Each monomer contains 115 amino acid residues and has a calculated molecular mass of approximately 14.5 kDa. |
Endotoxin : | < 1.0 eu per 1 μg of the cytokine as determined by the lal |
Purity : | >90%, as determined by SDS-PAGE and visualized by silver stain |
Storage : | Lyophilized samples are stable for up to six months at -20° C to -70° C. Upon reconstitution, this cytokine, in the presence of a carrier protein, can be stored under sterile conditions at 2 - 8° C for one month or at -20° C to -70° C in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL. |
Products Types
◆ Recombinant Protein | ||
Activin B-58H | Active Recombinant Human Activin B, CF | +Inquiry |
Activin B-16H | Active Recombinant Human Activin B, His-tagged | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionThe upregulation of activin-B and follistatin in IPF is a novel finding, suggesting their involvement in the disease.
The purpose of developing activin B-loaded hydrogels is to achieve sustained release of activin B over an extended period.
Activin B induces stress fiber formation and migration of BMSCs.
The sustained release of activin B from the hydrogels lasts for over 5 weeks.
The activin B-loaded hydrogels have shown substantial cellular protection and behavioral improvement.
Activin inhibition could be useful in reducing the alveolar cellular response to injury in IPF.
Yes, combining serum activin B concentration with free β-hCG improves the diagnostic potential for distinguishing tubal ectopic pregnancy from normal pregnancy.
Yes, activin B is produced endogenously in the body and is present in various tissues and fluids, including follicular fluid.
The serum activin B concentration is lower in tubal ectopic pregnancy compared to normal pregnancy.
Serum activin B concentration cannot reliably distinguish tubal ectopic pregnancy from intrauterine miscarriage (IUM).
Serum activin B concentration can discriminate tubal ectopic pregnancy from normal pregnancy with moderate accuracy.
The activin B-loaded hydrogels are being considered as a therapeutic strategy for Parkinson's disease.
Activin B is a member of the activin family, which is a group of growth and differentiation factors involved in various biological processes.
The purified activin B showed lower activity compared to other activins in various assay systems, such as follicle-stimulating hormone secretion and gonadotropin receptor expression.
No, it indicate that activin inhibition is not an efficient tool for antifibrotic therapy in IPF.
In porcine follicular fluid, the activin B-follistatin complex was found to be present in equimolar amounts, suggesting a tight interaction between the two proteins.
The findings suggest that the activin B-loaded hydrogels have the potential to be an effective therapeutic strategy for Parkinson's disease, based on the observed cellular protection and behavioral improvement.
Yes, activin-B and follistatin levels may be useful as biomarkers for IPF.
Activin B has been implicated in various biological functions, including embryonic development, cell differentiation, tissue repair, and regulation of hormone secretion.
Activin B can bind to follistatin, an activin-binding protein, to form a complex. This interaction helps regulate the activity and availability of activin B.
Customer Reviews (5)
Write a reviewThe protein product's efficacy has been validated by numerous independent research studies, solidifying its reputation as a highly effective reagent.
The company values customer satisfaction and has shown a commitment to providing exceptional support throughout our interactions.
The company employs rigorous quality control measures to ensure batch-to-batch consistency, guaranteeing reliable and reproducible outcomes.
The protein product is produced using advanced manufacturing processes and stringent quality standards, ensuring its integrity and reliability.
We have never experienced any issues with damage or contamination during shipping, thanks to the company's careful packaging and handling procedures.
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