Active Recombinant Human CDK8/CCNC, GST&His-tagged
Cat.No. : | CDK8/CCNC-256H |
Product Overview : | Coexpression of human CDK8, amino acids M1-Y464 (as in GenBank entry NM_001260), N-terminal GST-HIS6 fusion protein with a Thrombin cleavage site and human CycC, amino acids M1-S283 (as in GenBank entry NM_005190.3), N-terminally fused to HIS6-Thrombincleavage site. |
- Specification
- Gene Information
- Related Products
Description : | The Cdks are serine/threonine protein kinases which are predominantly involved in the progression of the cell cycle. Subsequently, CDK-cyclin complexes (CDK7, CDK8 and CDK9) were also identified as regulators of transcription. CDK8/CycC is part of the RNA polymerase II holoenzyme complex and phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. On the other hand, CDK8/CycC phosphorylates cyclin H, a component of the CDK activating kinase (CAK), and represses activated transcription by modulation of TFIIH activity. |
Source : | Baculovirus infected Sf9 cells |
Species : | Human |
Tag : | GST&His |
Bio-activity : | 17.000 pmol/mg x min |
Molecular Mass : | Theoretical MW MW GST-CDK8: 83.0 kDaTheoretical MW His-CyC: 38.0 kDa |
Concentration : | 0.43 mg/ml (Bradford method using BSA as standard protein) |
Storage Buffer : | 50 mM HEPES pH 7.5, 100 mM NaCl, 5 mM DTT, 20% glycerol |
Gene Name : | CDK8 cyclin-dependent kinase 8 [ Homo sapiens (human) ] |
Official Symbol : | CDK8 |
Synonyms : | cyclin-dependent kinase 8; K35; MGC126074; MGC126075; protein kinase K35; CDK8 protein kinase; cell division protein kinase 8; EC 2.7.11.22,EC 2.7.11.23; Protein kinase K35; CDK8; OTTHUMP00000018158; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8 |
Gene ID : | 1024 |
mRNA Refseq : | NM_001260 |
Protein Refseq : | NP_001251 |
MIM : | 603184 |
UniProt ID : | P49336 |
Chromosome Location : | 13q12 |
Pathway : | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants; Developmental Biology; FBXW7 Mutants and NOTCH1 in Cancer |
Function : | ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein serine/threonine kinase activity |
Products Types
◆ Recombinant Protein | ||
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CDK8-616R | Recombinant Rhesus Macaque CDK8 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK8-1531M | Recombinant Mouse CDK8 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK8-1039H | Active Recombinant Human CDK8 Protein, His-Tagged | +Inquiry |
CDK8-1038H | Active Recombinant Human CDK8 Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CDK8-7620HCL | Recombinant Human CDK8 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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