CDK2AP1
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Official Full Name
cyclin-dependent kinase 2 associated protein 1
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Overview
The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. -
Synonyms
CDK2AP1; cyclin-dependent kinase 2 associated protein 1; CDK2 associated protein 1; cyclin-dependent kinase 2-associated protein 1; doc 1; DOC1; DORC1; p12DOC 1; ST19; CDK2 A1; CDK2-associated protein 1; CDKA1; CDKA1_HUMAN; Cyclin dependent kinase 2 associated protein 1; Deleted in oral cancer 1; DOC 1 related protein; DOC 1R; DOC-1; DOC1R; Putative oral cancer suppressor; OTTHUMP00000239636; OTTHUMP00000239637; OTTHUMP00000239638; OTTHUMP00000239639; OTTHUMP00000239640; Deleted in oral cancer-1; p12DOC-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
CDK2AP1 involved in several pathways and played different roles in them. We selected most pathways CDK2AP1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CDK2AP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
CDK2AP1 has several biochemical functions, for example, DNA polymerase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDK2AP1 itself. We selected most functions CDK2AP1 had, and list some proteins which have the same functions with CDK2AP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA polymerase binding | FANCI;ACD;RAD51;PCNA;HMGB1;SMARCA4;LONP1;FANCD2;CDK2AP1 |
| protein binding | ASCC3;BFAR;SOX7;KHDC3;GATA2;RNF41;BBOX1;BST2;PLEKHG6 |
CDK2AP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDK2AP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDK2AP1.
MRFAP1L1; HDAC1; HDAC2; CCDC136; MTA2; MBD3
- Q&As
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