Active Recombinant Human IL21, Fc-tagged
Cat.No. : | IL21-337H |
Product Overview : | The extracellular domain of human IL-21 (aa 32-162) is fused to the N-terminus of the Fc region of a mutant human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of na?ve T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumors, leading to tumor rejection that is perforin dependent but IFN-gamma independent. |
Source : | CHO Cells |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Shows the biological function of the IL-21 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain. |
Purity : | ≥98% (SDS-PAGE) |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage : | Short Term Storage: +4°C; Long Term Storage: -20°C. Avoid freeze/thaw cycles. |
Gene Name : | IL21 interleukin 21 [ Homo sapiens ] |
Official Symbol : | IL21 |
Synonyms : | IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21; |
Gene ID : | 59067 |
mRNA Refseq : | NM_001207006 |
Protein Refseq : | NP_001193935 |
MIM : | 605384 |
UniProt ID : | Q9HBE4 |
Chromosome Location : | 4q26-q27 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
Function : | cytokine activity; cytokine receptor binding; interleukin-2 receptor binding; |
Products Types
◆ Recombinant Protein | ||
IL21-174H | Recombinant Active Human IL21 Protein, His-tagged(C-ter) | +Inquiry |
Il21-1672R | Recombinant Rat Il21 Protein, His-tagged | +Inquiry |
IL21-16H | Active Recombinant Human IL21 Protein, Fc-Avi-tagged, Biotinylated | +Inquiry |
Il21-361I | Active Recombinant Mouse Il21 Protein (123 aa) | +Inquiry |
IL21-2694R | Recombinant Rat IL21 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IL21-001RCL | Recombinant Rat IL21 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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