Active Recombinant Human IL21 Protein (Gln32-Ser162), GMP Grade, Animal-Free
Cat.No. : | IL21-20HG |
Product Overview : | GMP recombinant human IL-21 protein (Gln32-Ser162) with a N-terminal Met was expressed in E. coli, produced in an Animal-Free laboratory and manufactured and tested under cGMP guidelines |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Source : | E. coli |
Species : | Human |
Bio-activity : | Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is ≤8 ng/mL. |
Molecular Mass : | Predicted Molecular Mass: 15 kDa SDS-PAGE: 16 kDa, reducing conditions |
Protein Length : | Gln32-Ser162 |
N-terminal Sequence Analysis : | Met-Gln-Asp-Arg-His-Met-Ile-Arg-Met-Arg |
Endotoxin : | <0.10 EU/ μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. A minimum of 12 months when stored at ≤ -20 centigrade as supplied. Refer to lot specific COA for the Use by Date. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, ≤ -20 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution : | Reconstitute at 100-200 μg/mL in PBS. |
Shipping : | The product is shipped with polar packs. |
Gene Name : | IL21 interleukin 21 [ Homo sapiens ] |
Official Symbol : | IL21 |
Synonyms : | IL21; interleukin 21; interleukin-21; IL 21; Za11; interleukin-21 isoform; IL-21; |
Gene ID : | 59067 |
mRNA Refseq : | NM_001207006 |
Protein Refseq : | NP_001193935 |
MIM : | 605384 |
UniProt ID : | Q9HBE4 |
Products Types
◆ Recombinant Protein | ||
IL21-009D | Active Recombinant Dog IL21 Protein | +Inquiry |
IL21-01H | Active Recombinant Human IL21 Protein (aa 32-162), N-Fc-tagged | +Inquiry |
il21-4335S | Recombinant Salmon il21 Protein | +Inquiry |
IL21-362I | Active Recombinant Human IL21 Protein (132 aa) | +Inquiry |
Il21-361I | Active Recombinant Mouse Il21 Protein (123 aa) | +Inquiry |
◆ Lysates | ||
IL21-001RCL | Recombinant Rat IL21 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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