Active Recombinant Human NCOR1, GST-tagged
Cat.No. : | NCOR1-86H |
Product Overview : | Approximately 1:1 stoichiometric complex of recombinant human HDAC3 (histone deacetylase 3) with a GST fusion protein comprising the Deacetylase Activation Domain (DAD) of human NCOR1 (amino acids 397-503; SANT1 domain plus amino flanking residues). Produced by coexpression of HDAC3 with a GST-NCOR1(DAD) construct in an insect cell system, the complex displays ~100-fold higher deacetylase activity than isolated HDAC3. This HDAC3 preparation is active with various fluorogenic peptide substrates. |
- Specification
- Gene Information
- Related Products
Description : | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. |
Source : | Insect cells |
Species : | Human |
Tag : | GST |
Form : | Liquid. In 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol. |
Bio-activity : | ≥150 U/µg. One U=1 pmol/min at 37°C, 100 µM, “Fluor de Lys™-SIRT1” Substrate (p53 K(Ac)-382 fluorogenic substrate. |
Molecular Mass : | 49/40 kDa |
Purity : | ≥90% (SDS-PAGE) |
Storage : | -80°C |
Gene Name : | NCOR1 nuclear receptor corepressor 1 [ Homo sapiens ] |
Official Symbol : | NCOR1 |
Synonyms : | NCOR1; nuclear receptor corepressor 1; nuclear receptor co repressor 1; hCIT529I10; hN CoR; KIAA1047; MGC104216; N CoR; thyroid hormone and retinoic acid receptor associated corepressor 1; TRAC1; nuclear receptor co-repressor 1; thyroid hormone- and retinoic acid receptor-associated corepressor 1; N-CoR; N-CoR1; hN-CoR |
Gene ID : | 9611 |
mRNA Refseq : | NM_006311 |
Protein Refseq : | NP_006302 |
MIM : | 600849 |
UniProt ID : | O75376 |
Chromosome Location : | 17p11.2 |
Pathway : | Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Developmental Biology, organism-specific biosystem |
Function : | histone deacetylase binding; histone deacetylase regulator activity; protein binding; retinoid X receptor binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; thyroid hormone receptor binding; transcription corepressor activity; transcription corepressor activity; transcription regulatory region DNA binding |
Products Types
◆ Recombinant Protein | ||
HDAC3-4643H | Recombinant Human HDAC3 Protein, GST-tagged | +Inquiry |
HDAC3-1054H | Recombinant Human HDAC3 Protein, MYC/DDK-tagged | +Inquiry |
HDAC3-3099H | Recombinant Human HDAC3 Protein, His (Fc)-Avi-tagged | +Inquiry |
HDAC3-2235H | Recombinant Human HDAC3 Protein, His-tagged | +Inquiry |
HDAC3-1875R | Recombinant Rhesus Macaque HDAC3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HDAC3-572HCL | Recombinant Human HDAC3 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-2282 | HDAC3 Immunoprecipitation (IP) & Activity Assay Kit | +Inquiry |
Kit-1739 | HDAC3 Kinetic Assay Kit | +Inquiry |
Kit-2254 | HDAC3 Activity Fluorometric Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket