Active Recombinant Human PTPRF, GST-tagged
Cat.No. : | PTPRF-1524H |
Product Overview : | Recombinant human PTPRF (1275-1897) was expressed in E. coli cells using an N-terminal GST tag. |
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Description : | PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 454 nmol/min/mg |
Molecular Mass : | ~93 kDa |
Protein length : | 1275-1897 aa |
Purity : | >90% |
Applications : | Phosphatase Assay, Western Blot |
Storage : | Store at–70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens ] |
Official Symbol : | PTPRF |
Synonyms : | PTPRF; protein tyrosine phosphatase, receptor type, F; LAR; receptor-type tyrosine-protein phosphatase F; LCA-homolog; leukocyte common antigen related; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; receptor-linked protein-tyrosine phosphatase LAR; protein tyrosine phosphatase, receptor type, F polypeptide; FLJ43335; FLJ45062; FLJ45567; |
Gene ID : | 5792 |
mRNA Refseq : | NM_002840 |
Protein Refseq : | NP_002831 |
MIM : | 179590 |
UniProt ID : | P10586 |
Chromosome Location : | 1p34 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Insulin Signaling, organism-specific biosystem; Insulin signaling pathway, organism-specific biosystem; Insulin signaling pathway, conserved biosystem; |
Function : | hydrolase activity; insulin receptor binding; phosphate ion binding; protein tyrosine phosphatase activity; receptor activity; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine phosphatase activity; |
Products Types
◆ Recombinant Protein | ||
PTPRF-463H | Recombinant Human PTPRF Protein, His-tagged | +Inquiry |
PTPRF-4499R | Recombinant Rat PTPRF Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPRF-7286M | Recombinant Mouse PTPRF Protein, His (Fc)-Avi-tagged | +Inquiry |
PTPRF-6106H | Recombinant Human PTPRF Protein (Asp30-Tyr224), His tagged | +Inquiry |
PTPRF-2062H | Recombinant Human PTPRF, GST-tagged | +Inquiry |
◆ Lysates | ||
PTPRF-1439HCL | Recombinant Human PTPRF cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionPTPRF inhibitors can inhibit certain abnormal signaling pathways in autoimmune diseases, thereby exerting their role in the treatment of autoimmune diseases.
Specific PTPRF inhibitors can inhibit certain signaling pathways in the inflammatory response, thereby playing a role in the treatment of inflammatory diseases.
Knocking out the PTPRF gene may increase the risk of developing certain tumors, which may be related to aberrant regulation of cell cycle control and cell growth.
There are currently some studies that report specific PTPRF inhibitors that can inhibit the enzymatic activity of PTPRF and thus exert therapeutic effects.
Yes, soluble PTPRF proteins exist that can be detected in extracellular fluids and may play a role in regulating cell-to-cell communication and signal transduction.
Therapeutic strategies for PTPRF protein include increasing its expression level, inhibiting its enzymatic activity, and regulating its interaction with other proteins, which can be used to treat PTPRF protein-related diseases.
Customer Reviews (3)
Write a reviewQualitative is very strong, even after a lot of use can still maintain its structural and functional stability, which shows its excellent quality and reliability.
The reproducibility is very good, and I can get consistent results from each experiment, which makes me more confident in the experimental results.
Excellent performance in Western blot, avoiding interference problems in the experiment.
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