Active Recombinant Human Tumor Necrosis Factor (Ligand) Superfamily, Member 10
Cat.No. : | TNFSF10-4752H |
Product Overview : | Recombinant Human soluble Trail also called TNF-related apoptosis-inducing Ligand, TNFSF10, Apo2 Ligand AND TL2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 168 amino acids and having a molecular mass of 19.6 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TNFSF10-4752H |
Description : | In the field of cell biology, TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis. TRAIL has also been designated CD253 (cluster of differentiation 253). |
Species : | Human |
Source : | E.coli |
Form : | Lyophilized from a concentrated solution (1mg/ml) contains 150 mM NaCl, and 50mM sodium phosphate, pH 7.4. |
Purity : | Purity Greater than 95% as determined by: Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE. |
Bio-activity : | Recombinant Human TRAIL is fully biologically active when compared to standard. The activity is determined by the ability to induce apoptotic cell death in TRAIL-sensetive U343MG cells, ED50 for this effect is 1-3 ng/ml. |
Physical Appearance : | Sterile Filtered white lyophilized (freeze-dried) powder. |
Solubility : | Lyophilized rHuTRAIL although stable at room temperature for 3 weeks, should be stored desiccated below -18μ. Upon reconstitution rHuTRAIL should be stored at 4μ between 2-7 days and for future use below -18μ. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles |
Purity Greater than 95% as determined by : | Analysis by RP-HPLC. Reducing and non-reducing SDS-PAGE. |
Protein Content determined by : | UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard. |
Endotoxin Level : | Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug. |
Amino acid sequence : | MRERGPQRVA AHITGTRGRS NTLSSPNSKN EKALGRKINS WESSRSGHSF LSNLHLRNGE LVIHEKGFYY IYSQTYFRFQ EEIKENTKND KQMVQYIYKY TSYPDPILLM KSARNSCWSK DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG |
Storage : | Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage. |
Gene Name : | TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 [ Homo sapiens ] |
Official Symbol : | TNFSF10 |
Synonyms : | TNFSF10; tumor necrosis factor (ligand) superfamily, member 10; TRAIL; Apo-2L; TL2; CD253; Tumor necrosis factor ligand superfamily member 10; TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; APO2L; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; CD253 antigen; tumor necrosis factor apoptosis-inducing ligand splice variant delta |
Gene ID : | 8743 |
mRNA Refseq : | NM_003810 |
Protein Refseq : | NP_003801 |
MIM : | 603598 |
UniProt ID : | P50591 |
Chromosome Location : | 3q26 |
Pathway : | Apoptosis; Cytokine-cytokine receptor interaction; Natural killer cell mediated cytotoxicity |
Function : | cytokine activity; metal ion binding; tumor necrosis factor receptor binding; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
TNFSF10-03H | Active Recombinant Human TNFSF10 Protein (114-281), Tag-Free | +Inquiry |
TNFSF10-253H | Recombinant Human TNFSF10 Protein | +Inquiry |
Tnfsf10-6550M | Active Recombinant Mouse Tnfsf10 Protein | +Inquiry |
TNFSF10-9480M | Recombinant Mouse TNFSF10 Protein, His (Fc)-Avi-tagged | +Inquiry |
TNFSF10-302T | Active Recombinant Human TNFSF10 Protein (169 aa) | +Inquiry |
◆ Lysates | ||
TNFSF10-892HCL | Recombinant Human TNFSF10 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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