Active Recombinant Mouse A Disintegrin-Like And Metallopeptidase (reprolysin type) With Thrombospondin Type 1 Motif, 1, His-tagged

• Cat.No.: Adamts1-441M
• Product Overview: RecombinantMouse Adamts1proteinwas expressed in Chinese Hamster Ovary cell line. Phe254-Cys725,with a C terminal 10 His tag.

Specification

• Cat. No.: Adamts1-441M
• Description: Adamts1 is the foundingmember of the family of secreted zinc proteases with a multi domainstructure. The protein precursor consists of a signal peptide and the followingdomains: pro, catalytic, disintegrinlike, TS type 1 motif, cysteine rich,spacer and a variable number of thrombospondin type 1 Motifs. Based on theirsubstrate specificity, Adamts1 and associated familymembers may be key enzymes in the degradation of cartilage leading toinflammation and arthritis.
• Source: ChineseHamster Ovary cell line, CHO-derived.
• Form: Monomer.Recombinant Mouse Adamts1 is prone to proteolytic cleavage at C terminus.The predominant form of the purified protein lacks the His tag.
• N-terminalSequence: Phe254
• MolecularWeight: 53 kDa
• Activity: Measuredby its ability to cleave rhAggrecan. rm Adamts1 achieves > 50% substrate cleavage, as measured underthe described conditions. See Activity Assay Protocol.
• Endotoxin Level: <1.0EU per 1 ug of the protein by the LAL method.
• Purity: >95%,by SDSPAGE under reducing conditions and visualized by silver stain.
• Storage: Use a manual defrost freezer and avoid repeated freezethawcycles.6 months from date of receipt, 20 to 70°C as supplied. 3 months, 20 to 70°Cunder sterile conditions after opening.

Gene Information

• Gene Name: Adamts1 a disintegrin-like andmetallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 [ Musmusculus ]
• Official Symbol: Adamts1
• Synonyms: Adamts1; a disintegrin-likeand metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1; C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1;ADAMTS-1; A disintegrin and metalloproteinase with thrombospondin motifs 1;ADAM-TS 1; a disintegrin-like and metalloprotease (reprolysin type) withthrombospondin type 1 motif, 1
• Gene ID: 11504
• mRNA Refseq: NM_009621
• Protein Refseq: NP_033751
• UniProt ID: P97857
• Chromosome Location: 16
• Pathway: Endochondral Ossification
• Function: heparin binding; hydrolaseactivity; metal ion binding; metalloendopeptidase activity; metallopeptidaseactivity; peptidase activity; protein binding; zinc ion binding

Reviews

03/01/2021

Excellent after-sales service, solving many experimental problems.

06/30/2020

The products provided by your company are inexpensive and of high quality, and because of this, my experiments could be completed successfully.

09/03/2019

The price of the product is right and the quality meets my research needs.

Q&As

What is the structure domain of ADAMTS1?

Pro-peptide, metallo proteinase, depolymerase/cysteine enriched region, spacer region and thrombospondin type I repeat.

My customization requirements are not listed on the page, can it be customized?

Yes, you can first communicate with our experts for customized requirements.

Is it also possible to shorten the lead time for custom-manufactured proteins?

The delivery cycle of this kind of protein is related to your specific customization requirements, you can communicate with our experts first.

Do you offer ADAMTS1 protein fused with other tags?

We can provide ADAMTS1 protein fused with other tags.

Is ADAMTS1 widely used in disease research?

ADAMTS1 applied to a variety of diseases including colon, oesophageal and lung cancers.

What physiological and pathological processes is ADAMTS1 involved in?

ADAMTS1 is involved in the physiological and pathological processes of human growth and development, the formation of the urinary and reproductive systems, and the development of tumours in tissues and organs.

What are the consequences of ADAMTS1 inactivation?

Inactivation of ADAMTS1 causes infertility and developmental delay in females.

Is there a discount for all ADAMTS1 proteins?

Yes, all ADAMTS1 proteins are currently discounted.

What proteins does ADAMTS1 degrade?

ADAMTS1 degrades extracellular matrix proteins such as versican , aggrecan , syndecan and nidogen.

I saw that proteins can be customized, can I customize ADAMTS1 for specific bands?

Yes, our team can customize the protein according to your requirements.

What is the effect of adding trehalose on the preservation of protein?

Trehalose can prevent protein secondary structure changes, elongation and aggregation during freeze-drying.