Active Recombinant Mouse Bace2 Protein (20-462aa), C-His-tagged
Cat.No. : | Bace2-11M |
Product Overview : | Recombinant mouse BACE-2 (20-462aa), fused to His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques. |
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Description : | BACE-2, also known as beta secretase 2, belongs to the peptidase A1 family. It is an aspartic protease that is a close homolog of BACE-1. However, BACE-2 differs from BACE-1 in several aspects including pro-enzyme activation, substrate binding sites, transcriptional regulation, and function in Aβ peptide production. It has been shown to play a key role in insulin receptor trafficking in the pancreas where it is expressed in β cells and affects glucose tolerance and was suggested as a promising target for improving β cell function in diabetes. |
Source : | HEK293 |
Species : | Mouse |
Tag : | C-His |
Form : | Liquid |
Bio-activity : | Specific activity is > 20 pmol/min/μg in which one unit will convert 1.0 pmole of Mca-SEVNLDAEFRK(Dnp)RR-NH2 to Mca- Pro-Leu-OH per minute at pH 3.5 at 25 centigrade. |
Molecular Mass : | 48.6 kDa (449 aa) |
Protein Length : | 20-462 aa |
AA Sequence : | AVPALAPAPFTLPLQVARATNHRAS AVPGLGTPELPRADGLALALEPVRA TANFLAMVDNLQGDSGRGYYLEMLI GTPPQKVQILVDTGSSNFAVAGAPH SYIDTYFDSESSSTYHSKGFDVTVK YTQGSWTGFVGEDLVTIPKGFNSSF LVNIATIFESENFFLPGIKWNGILG LAYAALAKPSSSLETFFDSLVAQAK IPDIFSMQMCGAGLPVAGSGTNGGS LVLGGIEPSLYKGDIWYTPIKEEWY YQIEILKLEIGGQNLNLDCREYNAD KAIVDSGTTLLRLPQKVFDAVVEAV ARTSLIPEFSDGFWTGAQLACWTNS ETPWAYFPKISIYLRDENASRSFRI TILPQLYIQPMMGAGFNYECYRFGI SSSTNALVIGATVMEGFYVVFDRAQ RRVGFAVSPCAEIEGTTVSEISGPF STEDIASNCVPAQALNEP |
Endotoxin : | < 1 EU/μg of protein (determined by LAL method) |
Purity : | > 95% by SDS-PAGE |
Applications : | SDS-PAGE, Enzyme Activity |
Notes : | For research use only. This product is not intended or approved for human, diagnostics or veterinary use. |
Storage : | Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/mL (determined by Absorbance at 280 nm) |
Storage Buffer : | Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
Gene Name : | Bace2 beta-site APP-cleaving enzyme 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Bace2 |
Synonyms : | BACE2; beta-site APP-cleaving enzyme 2; beta-secretase 2; ASP1; asp 1; memapsin-1; theta-secretase; aspartyl protease 1; beta-site APP cleaving enzyme 2; membrane-associated aspartic protease 1; beta-site amyloid precursor protein cleaving enzyme 2; ARP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; AI850424; 1110059C24Rik |
Gene ID : | 56175 |
mRNA Refseq : | NM_019517 |
Protein Refseq : | NP_062390 |
UniProt ID : | Q9JL18 |
Products Types
◆ Recombinant Protein | ||
Bace2-1816M | Recombinant Mouse Bace2 Protein, Myc/DDK-tagged | +Inquiry |
Bace2-947M | Recombinant Mouse Bace2 Protein, His (Fc)-Avi-tagged | +Inquiry |
BACE2-588R | Recombinant Rat BACE2 Protein, His (Fc)-Avi-tagged | +Inquiry |
BACE2-33M | Active Recombinant Mouse BACE2 Protein, His-Tagged | +Inquiry |
BACE2-579TH | Active Recombinant Human BACE2, His-tagged | +Inquiry |
◆ Lysates | ||
BACE2-1388MCL | Recombinant Mouse BACE2 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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