Active Recombinant Mouse Casp1 Protein

• Cat.No.: Casp1-0413M
• Product Overview: Mouse Casp1 (P29452) recombinant protein expressed in Escherichia coli. This protein composed of large (20 KDa) and small (10 KDa) KDa) subunits.

Specification

• Description: Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells.
• Source: E. coli
• Species: Mouse
• Form: Lyophlized
• Bio-activity: 20000 units/mg
• Molecular Mass: 30 kDa
• Applications: Functional Study
  SDS-PAGE
• Storage: Store at -80 centigrade on dry atmosphere. After reconstitution with PBS containing 15% glycerol 1 uL per unit, store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: No additive

Gene Information

• Gene Name: Casp1 caspase 1 [ Mus musculus ]
• Official Symbol: Casp1
• Synonyms: CASP1; caspase 1; caspase-1; p45; CASP-1; IL-1BC; IL-1B converting enzyme; IL-1 beta-converting enzyme; interleukin-1 beta convertase; interleukin 1 beta-converting enzyme; interleukin-1 beta-converting enzyme; ICE; Il1bc
• Gene ID: 12362
• mRNA Refseq: NM_009807
• Protein Refseq: NP_033937