Caspase-3
Cat.No. : | CBCRY39 |
- Specification
- Gene Information
- Related Products
Cat. No. : | CBCRY39 |
Background : | Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer"s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. |
Protein Classification : | hydrolase |
Structure Weight : | 114694.18 Da |
Polymer : | 1 |
Molecule : | Caspase-3 |
Chain Length : | 253 amino acids |
PDB ID : | 3DEK |
MMDB ID : | 66481 |
Source : | E.coli |
Method : | X-Ray Diffraction |
Resolution : | 2.4Å |
Ligand Chemical Component : | Cysteinesulfonic acid |
Reference : | Du, J.-Q., Wu, J., Zhang, H.-J., Zhang, Y.-H., Qiu, B.-Y., Wu, F., Chen, Y.-H., Li, J.-Y., Nan, F.-J., Ding, J.-P., Li, J. (2008) Isoquinoline-1,3,4-trione Derivatives Inactivate Caspase-3 by Generation of Reactive Oxygen Species J.Biol.Chem. 283: 30205-30215 |
Gene Name : | CASP3 |
Synonyms : | CPP32; CPP32B; procaspase3; Yama; SCA-1; OTTHUMP00000165054; PARP cleavage protease; SREBP cleavage activity 1; apopain; caspase 3; caspase 3, apoptosis-related cysteine protease; cysteine protease CPP32; |
UniProt ID : | P42574 |
Gene ID : | 836 |
Chromosome Location : | 4q34 |
Function : | cysteine-type endopeptidase activity; cyclin-depedent protein kinase inhibitor activity; peptidase activity; cysteine-type peptidase activity; hydrolase activity |
Products Types
◆ Recombinant Protein | ||
CASP3-507H | Recombinant Human CASP3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Casp3-771M | Recombinant Mouse Casp3 Protein, MYC/DDK-tagged | +Inquiry |
CASP3-0421H | Recombinant Human CASP3 Protein, GST-Tagged | +Inquiry |
CASP3-0594H | Recombinant Human CASP3 Protein (M1-H277), Tag Free | +Inquiry |
CASP3-624H | Recombinant Human CASP3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CASP3-7839HCL | Recombinant Human CASP3 293 Cell Lysate | +Inquiry |
CASP3-7838HCL | Recombinant Human CASP3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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