Active Recombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged
Cat.No. : | Fgfr2-551M |
Product Overview : | Recombinant Mouse Fgfr2protein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330 (C-terminus) and Arg22-Glu378 & Asn314His (N-terminus). |
- Specification
- Gene Information
- Related Products
Cat. No. : | Fgfr2-551M |
Description : | Fibroblast growthfactor receptor 2 alpha (Fgfr2α) is a 140 kDa type I transmembrane receptortyrosine kinase that mediates the heparan sulfate proteoglycandependentbiological activity of several FGFs. It is a member of the FGFR family ofproteins whose extracellular domains contain three immunoglobulin-Ig-likedomains with a series of acidic residues between the first and second Ig-likedomains. Multiple forms of Fgfr2 are generated by alternative splicing. Alphaisoforms contain all three Ig-like domains, while beta forms lack the firstIg-like domain. |
Source : | Mammalian cells |
Form : | Lyophilized from a0.2 μm filtered solution in PBS. |
N-terminalSequence : | Arg22, Ser24, andLeu27 |
Molecular Weight : | 66.2 kDa |
Activity : | Measuredby its binding ability in a functional ELISA. 200 ng/mL of biotinylatedrmFGF1 is mixed with serially diluted rmFgfr2α (IIIb)/Fc. Followingincubation, the gfr2α (IIIb)/Fc FGF1/ biotin complex is captured on aStreptavidin coated plate. Bound Fgfr2α (IIIb)/Fc is measured using HRPlabeled Gt x Human IgG Fc. The concentration of rmFgfr2α (IIIb)/Fc thatproduces 50% of the optimal binding was found to be approximately 150-600ng/mL. |
Endotoxin Level : | <1.0 EUper 1 μg of the protein by the LAL method. |
SDS-PAGE : | 105-120kDa, reducing conditions |
Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | Reconstituteat 100 μg/mL in sterile PBS |
Storage : | Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution. |
Gene Name : | Fgfr2 fibroblast growth factorreceptor 2 [ Mus musculus ] |
Official Symbol : | Fgfr2 |
Synonyms : | Fgfr2;fibroblast growth factor receptor 2; Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7;KGFRTr; AU043015; AW556123; fibroblast growth factor receptor 2; keratinocytegrowth factor receptor; EC 2.7.10.1; CD332; Ect1 |
Gene ID : | 14183 |
mRNA Refseq : | NM_010207 |
Protein Refseq : | NP_034337 |
UniProt ID : | P21803 |
Chromosome Location : | 7 F3; 7 |
Pathway : | Downstream signalingof activated FGFR; ESC Pluripotency Pathways; FGFR ligand binding andactivation; FGFR2 ligand binding and activation; IRS-mediated signalling;IRS-related events; Insulin receptor signalling cascade; MAPK signalingpathway; PI-3K cascade; Pathways in cancer; Phospholipase C-mediated cascade;Regulation of Actin Cytoskeleton; Endocytosis; Signaling by FGFR; Signalingby Insulin receptor |
Function : | ATP binding;fibroblast growth factor 1 binding; fibroblast growth factor binding;fibroblast growth factor-activated receptor activity; heparin binding; kinaseactivity; nucleotide binding; protein binding; protein homodimerizationactivity; protein kinase activity; protein tyrosine kinase activity; receptoractivity; transferase activity; transmembrane receptor protein tyrosinekinase activity |
Products Types
◆ Recombinant Protein | ||
FGFR2-5418H | Recombinant Human Fibroblast Growth Factor Receptor 2, His-tagged | +Inquiry |
FGFR2-34H | Recombinant Active Human FGFR2 (N549K) Protein (285-end), N-GST-tagged | +Inquiry |
FGFR2-705H | Active Recombinant Human FGFR2 protein(Met1-Glu377), His&hFc-tagged | +Inquiry |
FGFR2-2055H | Recombinant Human FGFR2 Protein, DDK-tagged | +Inquiry |
FGFR2-058H | Recombinant Human FGFR2 Protein | +Inquiry |
◆ Lysates | ||
FGFR2-428HCL | Recombinant Human FGFR2 cell lysate | +Inquiry |
FGFR2-001MCL | Recombinant Mouse FGFR2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0341 | FGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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