Active Recombinant Rat Interleukin-17E (IL-25)

• Cat.No.: IL25-495R
• Product Overview: Recombinant rat IL-17E produced in E.coli is a nonglycosylated disulfide-joined homodimer having a molecular mass of 35.5 kDa.

Specification

• Cat. No.: IL25-495R
• Description: Rat IL-17E (IL-17), is a proinflammatory cytokine member of a six-species family of proteins (IL-17A-17F). Rat IL-17E protein is a homodimer consisting of two 145 amino acids peptides.
• Species: Rat
• Source: E.coli
• Form: Lyophilized with no additives.
• Purity: Purity Greater than 97% as determined by: Reducing and non-reducing SDS-PAGE.
• Bio-activity: Rat IL-17E activity is measured by the dose-dependent induction of mG-CSF production in cultured NIH 3T3 cells. The dose range for this activity is 10-100ng/ml.
• Physical Appearance: Sterile Filtered white lyophilized (freeze-dried) powder.
• Solubility: It is recommended to reconstitute the lyophilized product with sterile 20 mM HCl at a concentration of 0.1 mgμs/ml. Further dilutions into other buffers can be made.
• Purity Greater than 97% as determined by: Reducing and non-reducing SDS-PAGE.
• Protein Content determined by: UV spectroscopy at 280 nm. Quantitation on SDS-PAGE against a known standard.
• Endotoxin Level: Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
• Amino acid sequence: CSHLPRCCPS KQQEFPEEWL KWNPAPVSPP EPLRHTHHPE SCRASKDGPL NSRAISPWSY ELDRDLNRVP QDLYHARCLC PHCVSLQTGS HMDPMGNSVP LYHNQTVFYR RPCHGEQGAH GRYCLERRLY RVSLACVCVR PRMMA
• Storage: Lyophilized product is very stable at -20 degrees. Reconstituted material should be aliquoted and frozen at -20. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.

Gene Information

• Gene Name: Il25 interleukin 25 [ Rattus norvegicus ]
• Official Symbol: IL25
• Synonyms: Il25; interleukin 25; RGD1561632; rgd1561632_predicted; similar to IL25; similar to il25 (predicted); similar to IL25 (predicted); RGD1561632_predicted; LOC501996
• Gene ID: 501996
• mRNA Refseq: XM_577423
• Protein Refseq: XP_577423
• Chromosome Location: 15p13
• Pathway: Cytokine-cytokine receptor interaction
• Function: cytokine activity

Reviews

01/29/2021

The activity is very strong and can meet my research needs.

08/31/2019

Price is very reasonable and good value for money.

01/05/2019

It is very stable and can be stored and used for a long time.

Q&As

Is there any research showing that IL-25 is effective in tumor treatment?

There is a lack of conclusive evidence that IL-25 has a clear effect in tumor treatment, but there are some studies underway.

Are there any side effects to IL-25?

There are no clear studies on the side effects of IL-25, but the patient response needs to be closely monitored during research and clinical application.

Has the study found potential applications of IL-25 in the treatment of other diseases?

In addition to treating asthma and inflammatory bowel disease, IL-25 may also have potential applications in the treatment of lung infections, urticaria and other diseases.

What is the mechanism of action of IL-25?

IL-25 activates specific signaling pathways by binding to specific receptors, thereby regulating the activity of immune cells and the degree of inflammation in the body.

Is there any research showing that IL-25 is effective against certain diseases?

Some studies have shown that recombinant IL-25 can improve symptoms of diseases such as asthma and inflammatory bowel disease, but more research is needed to verify its efficacy.

Does IL-25 therapy need to be administered by injection?

Yes, in general, IL-25 therapy needs to be administered by injection to ensure that the protein can enter the body and work.