Recombinant Rat Tnfsf15 protein(Asp94-Ile252), hFc-tagged

• Cat.No.: Tnfsf15-8724R
• Product Overview: Recombinant Rat TNFSF15 (Q8K3Y7) (Asp94-Ile252) was expressed in HEK293, fused with the Fc region of Human IgG1 at the N-terminus.

Specification

• Source: HEK293
• Species: Rat
• Tag: N-hFc
• Protein length: Asp94-Ile252
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant rat TNFSF15/Fc is a disulfide-linked homodimer. The reduced monomer comprises 419 amino acids and has a predicted molecular mass of 46.5 kDa. The apparent molecular mass of the protein is approximately 55 kDa in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 90 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: Tnfsf15 tumor necrosis factor (ligand) superfamily, member 15 [ Rattus norvegicus ]
• Official Symbol: Tnfsf15
• Synonyms: TNFSF15; tumor necrosis factor (ligand) superfamily, member 15; tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; vascular endothelial cell growth inhibitor
• Gene ID: 252878
• mRNA Refseq: NM_145765
• Protein Refseq: NP_665708

Reviews

03/21/2022

They keep up with the latest research findings and continually refine their product based on customer feedback and emerging scientific trends.

05/01/2021

Their prompt assistance and prompt response can swiftly resolve any challenges, enabling smooth experimentation and maintaining the integrity of the results.

10/01/2017

Their knowledgeable support team is well-equipped to address specific inquiries, suggest experimental protocols, and provide guidance throughout the entire research process.

Q&As

How does TNFSF15 interact with other components of the immune system?

TNFSF15 interacts with receptors on immune cells, influencing their activity and contributing to the overall regulation of immune responses.

Are there any current clinical trials targeting TNFSF15 for autoimmune disease treatments?

Several clinical trials are underway to evaluate the efficacy and safety of therapies targeting TNFSF15 in autoimmune diseases.

Are there any diagnostic implications of TNFSF15 in autoimmune disorders?

TNFSF15 levels may serve as a biomarker for certain autoimmune conditions, aiding in the diagnosis and monitoring of disease progression.

Can TNFSF15 be a potential target for novel drug development in autoimmune diseases?

TNFSF15 is considered a promising target for drug development, and ongoing research aims to identify compounds that modulate its activity effectively.

How does TNFSF15 contribute to the pathogenesis of inflammatory bowel disease (IBD)?

In IBD, TNFSF15 is believed to be involved in the inflammation process, contributing to the chronic nature of the disease.