Recombinant Human Interleukin 6 (interferon, beta 2)

• Cat.No.: IL6-62H
• Product Overview: Recombinant Human Interleukin-6 produced inCHOis a single, glycosylated polypeptide chain containing 185 amino acids and migrates at 22 kDa as a glycosilated protein on SDS-PAGE. The IL6 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: IL6-62H
• Description: IL-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of b-cells into ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
• Source: Chinese Hamster Ovarian Cells.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Purity: Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: Lyophilized from a solution containing Phosphate- Buffered Saline pH-7.4.
• Solubility: It is recommended to reconstitute the lyophilized Interleukin-6 in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: The activity was measured in a cell prolifiration assay using B9 cells. The ED₅₀for this effect is 8-20 pg/ml.
• Storage: Lyophilized Interleukin-6 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL6 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ]
• Synonyms: IL6; interleukin 6 (interferon, beta 2); HGF; HSF; BSF2; IL-6; IFNB2;B-cell stimulatory factor 2; BSF-2; Interferon beta-2; Hybridoma growth factor; CTL differentiation factor; CDF; B cell stimulatory factor-2; B-cell differentiation factor; interleukin 6; interleukin BSF-2
• Gene ID: 3569
• mRNA Refseq: NM_000600
• Protein Refseq: NP_000591
• UniProt ID: P05231
• Chromosome Location: 7p21
• MIM: 147620
• Pathway: Cytokine-cytokine receptor interaction; Graft-versus-host disease; Hematopoietic cell lineage; Hypertrophic cardiomyopathy (HCM); Jak-STAT signaling pathway; Pathways in cancer; Prion diseases; Toll-like receptor signaling pathway
• Function: cytokine activity; growth factor activity; interleukin-6 receptor binding

Reviews

03/05/2022

Accurate localization and function within the cell.

01/31/2021

The binding affinity and affinity constant with the target are high.

03/12/2020

Can form a stable micellar structure.

Q&As

What is the dosage and usage of Il6?

The dosage and usage of Il6 will vary according to the disease, and generally require individualized regulation by the physician according to the disease situation.

What are the pharmacokinetic properties of Il6?

The pharmacokinetic characteristics of Il6 mainly include drug absorption, distribution, metabolism, excretion and other information.

Does Il6 have advantages in the treatment of multiple myeloma?

Recombinant Il6 protein has a unique therapeutic advantage in the treatment of multiple myeloma. It can promote the proliferation and differentiation of hematopoietic stem cells and inhibit the growth of tumor cells.

Does Il6 have specific therapeutic effects for certain diseases?

Il6 has specific therapeutic effects for certain diseases, such as rheumatoid arthritis, multiple myeloma and so on.

In which diseases is Il6 widely used?

This protein is widely used in the treatment of rheumatoid arthritis, pneumonia, multiple myeloma, lymphoma, malignant tumors and other diseases.

What is the effect of Il6 on immune cells?

The effects of Il6 on immune cells are mainly manifested as promoting cell proliferation and differentiation, regulating immune response, etc.