Recombinant Human CHRNA5, GST-tagged

• Cat.No.: CHRNA5-11213H
• Product Overview: Recombinant Human CHRNA5 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 30-250a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) [ Homo sapiens ]
• Official Symbol: CHRNA5
• Synonyms: CHRNA5; cholinergic receptor, nicotinic, alpha 5 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 5; neuronal acetylcholine receptor subunit alpha-5; acetylcholine receptor; nicotinic; alpha 5 (neuronal); acetylcholine receptor, nicotinic, alpha 5 (neuronal); neuronal nicotinic acetylcholine receptor, alpha5 subunit; Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5; LNCR2
• Gene ID: 1138
• mRNA Refseq: NM_000745
• Protein Refseq: NP_000736
• MIM: 118505
• UniProt ID: P30532
• Chromosome Location: 15q24
• Pathway: Acetylcholine Binding And Downstream Events, organism-specific biosystem; Activation of Nicotinic Acetylcholine Receptors, organism-specific biosystem; Highly calcium permeable nicotinic acetylcholine receptors, organism-specific biosystem; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; Neuronal System, organism-specific biosystem
• Function: acetylcholine binding; acetylcholine receptor activity; acetylcholine-activated cation-selective channel activity; acetylcholine-activated cation-selective channel activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activit