Active Recombinant Mouse IL15RA, MIgG2a Fc-tagged

• Cat.No.: IL15RA-1553M
• Product Overview: The extracellular domain of mouse IL-15RA (NP_032384.1)(Gly33-Lys205) is fused to the N-terminus of the Fc region of a mouse IgG2a was expressed in CHO cell.

Specification

• Description: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.
• Source: CHO cell
• Species: Mouse
• Tag: MIgG2a Fc-tagged
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to block human IL-15-induced proliferation of CTLL 2 mouse cytotoxic T cells.
• Molecular Mass: 45KDa (monomer)
• AA Sequence: Gly33-Lys205
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Il15ra interleukin 15 receptor, alpha chain [ Mus musculus ]
• Official Symbol: IL15RA
• Synonyms: IL15RA; interleukin 15 receptor, alpha chain; interleukin-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; IL-15 receptor subunit alpha; AA690181
• Gene ID: 16169
• mRNA Refseq: NM_008358
• Protein Refseq: NP_032384
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem
• Function: receptor activity