Recombinant Rat Il6r, His-tagged

• Cat.No.: Il6r-935R
• Product Overview: A DNA sequence encoding the rat Il6r (Met1-Pro364) was expressed with a polyhistidine tag at the C-terminus.

Specification

• Description: Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
• Source: Human Cells
• Species: Rat
• Tag: His
• Predicted N Terminal: Leu 20
• Form: Lyophilized from sterile PBS, pH 7.4.
• Molecular Mass: The recombinant rat Il6r consists 356 amino acids and predicts a molecular mass of 39.5 kDa.
• Endotoxin: <1.0 EU per μg protein as determined by the LAL method.
• Purity: > 90 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: Il6r interleukin 6 receptor [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Il6r
• Synonyms: Il6r; IL6R1; Il6ra; interleukin 6 receptor; interleukin-6 receptor subunit alpha; IL-6RA; IL-6R 1; IL-6R-alpha; IL-6R subunit alpha; IL-6 receptor subunit alpha; interleukin 6 receptor, alpha
• Gene ID: 24499
• mRNA Refseq: NM_017020
• Protein Refseq: NP_058716
• UniProt ID: P22273
• Chromosome Location: 2q34
• Pathway: Cytokine Signaling in Immune system; HIF-1 signaling pathway; Hematopoietic cell lineage
• Function: ciliary neurotrophic factor binding; contributes_to ciliary neurotrophic factor receptor activity; interleukin-6 binding

Reviews

02/23/2022

Good compatibility and stability with the surfactant.

11/23/2020

Expression level and stability of clones were good.

02/01/2019

Remarkable antibacterial activity and bactericidal effect on bacteria.

Q&As

What is the dose and route of administration of IL6R?

The dose and route of administration need to be determined according to the specific treatment situation. Common routes of administration include subcutaneous injection and intravenous injection.

Can recombinant IL6R be used in autoimmune diseases?

It can be used to treat certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.

Can recombinant IL6R be used to prevent disease?

The IL6R is primarily used to treat inflammatory diseases that have already occurred, rather than prevent them.

How the action mechanism of IL6R?

IL6R reduces inflammation by binding to interleukin-6 (IL-6), blocking the IL-6 signaling pathway.

Does IL6R have anti-tumor effects?

Although IL6R can regulate the immune system, it is not a direct anti-tumor drug.

How to evaluate the efficacy of IL6R?

The efficacy of IL6R is usually evaluated based on improvement of clinical symptoms, changes in disease activity, and changes in biochemical markers.