| Cat. No. : |
IL27RA-781H |
| Description : |
L27Rα (IL27R), also well known as WSX-1 and TCCR, is a type I cytokine receptor that functions only as the ligand binding component of the receptor for IL27, and together with the glycoprotein 130 (gp130) coreceptor constitutes a functional signal-transducing receptor mediating the IL27 effects. Neither receptor chain alone is sufficient independent of the other. As a member of the IL6/IL12 family of cytokines, IL27 is not only involved in the development of Th1-type adaptive immune response, but also acts on cells of the innate immune system. In addition, it has been demonstrated that IL27Rα, the single component of a heterodimeric cytokine receptor, can aberrantly activate signaling pathways and transform hematopoietic cells in a JAK-dependent manner in acute myeloid leukemia (AML). Accordingly, IL27Rα may play an unappreciated role in various myeloproliferative disorders (MPDs) and be identified as a future therapeutic target for this disease. |
| Molecular Mass : |
The recombinant human IL27Rα/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. The reduced monomer consists of 722 amino acids and has a predicted molecular mass of 79kDa. As a result of glycosylation, the rh IL27Rα/Fc monomer migrates as an approximately 105-115kDa band in SDS-PAGE under reducing conditions. |
| Source : |
Escherichia Coli. |
| Predicted N Terminal : |
Gln 21. |
| Endotoxin : |
<1.0EU per 1μg cytokine as determined by the LAL method. |
| Formulation : |
Supplied as a 0.2μm filtered solution of PBS, pH7.2. |
| Reconstitution : |
Follow the instructions on the vial. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
| Purity : |
>95%, as determined by SDS-PAGE. |
| Stability : |
Samples are stable for up to twelve months from date of receipt -70°C. |
| Storage : |
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage and be used as soon as possible. Avoid repeated freeze-thaw cycles. |
