Recombinant Human TNFRSF10B, Fc-His tagged

• Cat.No.: TNFRSF10B-884H
• Product Overview: Recombinant Human TNFRSF10B extracellular domain (NP_003833.3) (Met 1-Glu 182), fused with the polyhistidine-tagged Fc region of human IgG1 at the C-terminus, was produced in Human Cell.

Specification

• Source: Human Cells
• Species: Human
• Tag: Fc-His
• Form: Lyophilized from sterile PBS, pH 7.4
• Molecular Mass: The recombinant human TNFRSF10B/Fc is a disulfide-linked homodimer. The reduced monomer consists of 375 amino acids and has a predicted molecular mass of 42.4 kDa. As a result of glycosylation, the apparent molecular mass of rh TNFRSF10B/Fc monomer migrates with an apparent molecular mass of 50 kDa in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Stability: Samples are stable for up to twelve months from date of receipt at -70oC.
• Storage: Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens ]
• Official Symbol: TNFRSF10B
• Gene ID: 8795
• mRNA Refseq: NM_003842
• Protein Refseq: NP_003833
• MIM: 603612
• UniProt ID: O14763

Reviews

08/11/2020

The combination of high-quality TNFRSF10B protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

10/07/2018

The manufacturer's extensive experience and expertise in the field of TNFRSF10B protein research make them a trusted partner.

03/04/2017

The manufacturer's commitment to providing excellent technical support is highly valuable.

Q&As

How does TNFRSF10B activation induce apoptosis in cancer cells?

Activation of TNFRSF10B triggers apoptotic pathways, leading to programmed cell death in cancer cells.

Is TNFRSF10B involved in other diseases besides cancer?

TNFRSF10B has been implicated in certain autoimmune diseases and neurodegenerative disorders, highlighting its diverse roles in various physiological processes.

Can TNFRSF10B be used as a diagnostic marker for cancer?

TNFRSF10B expression levels may serve as a potential diagnostic marker for certain cancers, aiding in cancer detection and prognosis.

In what types of cancer is TNFRSF10B expression altered?

TNFRSF10B expression is often altered in various cancers, including breast cancer, colorectal cancer, and lung cancer.

Are there any side effects associated with targeting TNFRSF10B in cancer treatment?

Side effects may occur, and ongoing research aims to minimize these effects while maximizing the therapeutic benefits of targeting TNFRSF10B.