Recombinant Human Tyrosine Kinase, Non-receptor, 2, GST-tagged, Active
Cat.No. : | ACK-234H |
Product Overview : | Recombinant human ACK (110-476) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=66 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | ACK-234H |
Description : | ACK is a tyrosine kinase that binds CDC42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42Hs. Overexpression of ACK in cancer cell lines of epithelial origin increases cellular motility and invasiveness. In a mouse model, ACK overexpression enhances the ability of a human breast cancer cell line to metastasize to the lung and increased mortality. Ligand stimulation of alpha-3 beta-1 integrin leads to activation of ACK which then enhances p130CAS phosphorylation and activation of RAC. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 110-476. |
Applications : | Kinase Assay, Western Blot. |
Stability : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | TNK2 tyrosine kinase, non-receptor, 2 [ Homo sapiens ] |
Synonyms : | TNK2; tyrosine kinase, non-receptor, 2; ACK; ACK1; FLJ44758; FLJ45547; p21cdc42Hs; activated p21cdc42Hs kinase; activated Cdc42-associated kinase 1; EC 2.7.10.2 |
Gene ID : | 10188 |
mRNA Refseq : | NM_001010938 |
Protein Refseq : | NP_001010938 |
MIM : | 606994 |
UniProt ID : | Q07912 |
Chromosome Location : | 3q29 |
Function : | ATP binding; GTPase inhibitor activity; non-membrane spanning protein tyrosine kinase activity; magnesium ion binding; protein binding; transferase activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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