ACK
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Official Full Name
CG14992 gene product from transcript CG14992-RA
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Overview
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and;GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence;of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the;GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction;pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length;nature of only two transcript variants has been determined. -
Synonyms
NK2; tyrosine kinase, non-receptor, 2; ACK; ACK1; FLJ44758; FLJ45547; p21cdc42Hs; activated p21cdc42Hs kinase; activated Cdc42-associated kinase 1; EC 2.7.10.2; TNK2; tyrosine kinase, non-receptor, 2; Nefa; Calnuc; AI607786;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ACK-234H | Recombinant Human Tyrosine Kinase, Non-receptor, 2, GST-tagged, Active | Sf9 Insect Cell | GST |
ACK involved in several pathways and played different roles in them. We selected most pathways ACK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ACK has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ACK itself. We selected most functions ACK had, and list some proteins which have the same functions with ACK. You can find most of the proteins on our site.
Function | Related Protein |
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ACK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACK here. Most of them are supplied by our site. Hope this information will be useful for your research of ACK.
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Q&As (9)
Ask a questionTyrosine kinase plays a crucial role in immune cell signaling and response. For example, activation of tyrosine kinase receptors on T cells and B cells can lead to downstream signaling pathways that regulate cell activation, proliferation, and differentiation. In addition, non-receptor tyrosine kinases such as Syk and ZAP-70 are critical for immune cell signaling and response.
There are several methods used to study tyrosine kinase activity, such as western blotting, immunoprecipitation, and kinase assays. These methods can detect changes in tyrosine kinase activity and downstream signaling pathways in response to different stimuli.
Mutations in tyrosine kinase genes can lead to constitutive activation of tyrosine kinase, which can promote uncontrolled cell growth and tumorigenesis. This activation can occur through various mechanisms, such as ligand-independent activation, increased expression of the tyrosine kinase receptor, or loss of negative regulatory mechanisms.
There are several drugs that target tyrosine kinases, such as imatinib, erlotinib, and gefitinib. These drugs are used in the treatment of various cancers, such as chronic myeloid leukemia, non-small cell lung cancer, and gastrointestinal stromal tumors.
Aberrant tyrosine kinase activity has been implicated in various diseases, including cancer, autoimmune disorders, and cardiovascular diseases. Mutations in tyrosine kinase genes can result in constitutive activation of tyrosine kinase, leading to uncontrolled cell growth and tumorigenesis.
Activation of tyrosine kinase can lead to various downstream effects, such as changes in gene expression, cell proliferation, differentiation, and survival. These effects are mediated by downstream signaling pathways that are activated by phosphorylation of specific substrates.
The activity of tyrosine kinase is regulated by various mechanisms, including ligand binding, dimerization, and phosphorylation. Inhibition of tyrosine kinase activity is also regulated by protein phosphatases that remove the phosphate group from the substrate protein.
There are two types of tyrosine kinase receptors: receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases. RTKs are transmembrane receptors that are activated by ligand binding, such as growth factors. Non-receptor tyrosine kinases are cytoplasmic proteins that are activated by intracellular signals, such as cytokines.
Tyrosine kinases are activated by ligand binding to their associated receptors on the cell surface. This activation leads to autophosphorylation of the tyrosine kinase domain, which then phosphorylates downstream substrates. The phosphorylated substrates recruit other signaling molecules to form signaling complexes that propagate the signal downstream to regulate cellular processes.
Customer Reviews (2)
Write a reviewExcellent experimental data was obtained using this product ACK!
The product information is comprehensive and easy to use
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