Recombinant Human ALK

• Cat.No.: ALK-26499TH
• Product Overview: Recombinant fragment, corresponding to amino acids 426-528 of Human ALK

Specification

• Description: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).
• Source: E. coli
• Tissue specificity: Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
• Form: Liquid
• Purity: Purified via GST Tag
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.Contains 1 LDL-receptor class A domain.Contains 2 MAM domains.Contains 1 protein kinase domain.

Gene Information

• Gene Name: ALK anaplastic lymphoma receptor tyrosine kinase [ Homo sapiens ]
• Official Symbol: ALK
• Synonyms: ALK; anaplastic lymphoma receptor tyrosine kinase; anaplastic lymphoma kinase (Ki 1); ALK tyrosine kinase receptor; CD246
• Gene ID: 238
• mRNA Refseq: NM_004304
• Protein Refseq: NP_004295
• MIM: 105590
• Uniprot ID: Q9UM73
• Chromosome Location: 2p23
• Function: ATP binding; NF-kappaB-inducing kinase activity; nucleotide binding; receptor activity; transmembrane receptor protein tyrosine kinase activity