Recombinant Human CLK1

• Cat.No.: CLK1-27274TH
• Product Overview: Recombinant full length Human CLK1 with N terminal proprietary tag, predicted mwt: 79.31 kDa.

Specification

• Description: This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.
• Protein length: 484 amino acids
• Molecular Weight: 79.310kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQE NKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDY TQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIH HSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSAR YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYC EAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIV FELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPD IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPC DVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPK HMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFM LSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLL KKSI
• Sequence Similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: CLK1 CDC-like kinase 1 [ Homo sapiens ]
• Official Symbol: CLK1
• Synonyms: CLK1; CDC-like kinase 1; dual specificity protein kinase CLK1
• Gene ID: 1195
• mRNA Refseq: NM_001162407
• Protein Refseq: NP_001155879
• MIM: 601951
• Uniprot ID: P49759
• Chromosome Location: 2q33
• Pathway: Legionellosis, organism-specific biosystem; Legionellosis, conserved biosystem; mRNA processing, organism-specific biosystem
• Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity