Recombinant Human GHR
Cat.No. : | GHR-28188TH |
Product Overview : | Human Growth hormone receptor Recombinant fragment containing 237 amino acids, M.W. 28.1kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. |
Source : | E. coli |
Tissue specificity : | Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is hig |
Biological activity : | Biological Activity: GHR-28188TH is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH. |
Form : | Lyophilised:It is recommended to reconstitute the lyophilized Growth Hormone Binding Protein in sterile 18MO-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: None.Constituents: 0.0045mM Sodium bicarbonate. |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the type I cytokine receptor family. Type 1 subfamily.Contains 1 fibronectin type-III domain. |
Gene Name : | GHR growth hormone receptor [ Homo sapiens ] |
Official Symbol : | GHR |
Synonyms : | GHR; growth hormone receptor; |
Gene ID : | 2690 |
mRNA Refseq : | NM_000163 |
Protein Refseq : | NP_000154 |
MIM : | 600946 |
Uniprot ID : | P10912 |
Chromosome Location : | 5p14-p12 |
Pathway : | Androgen Receptor Signaling Pathway, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endochondral Ossification, organism-specific biosystem; |
Function : | SH2 domain binding; growth factor binding; growth hormone receptor activity; peptide hormone binding; proline-rich region binding; |
Products Types
◆ Recombinant Protein | ||
GHR-280H | Recombinant Human GHR Protein, Fc-tagged | +Inquiry |
GHR-555H | Recombinant Human GHR Protein, Biotinylated | +Inquiry |
Ghr-4090R | Recombinant Rat Ghr protein(Met1-Arg265), His-tagged | +Inquiry |
GHR-1279R | Acitve Recombinant Rat GHR protein(Met1-Arg265), hFc-tagged | +Inquiry |
Ghr-3269M | Active Recombinant Mouse Ghr protein(Met1-Gln273), His-tagged | +Inquiry |
◆ Lysates | ||
GHR-1140RCL | Recombinant Rat GHR cell lysate | +Inquiry |
GHR-2401MCL | Recombinant Mouse GHR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket