Recombinant Human IL12A, His-tagged

• Cat.No.: IL12A-29635TH
• Product Overview: Recombinant fragment, corresponding to amino acids 57-253 of mature Human IL12 p35 with an amino-terminal hexahistidine tag.

Specification

• Description: This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 20mM Tris, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: RNLP VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS EEIDHEDITK DKTSTVEACLPLELTKNESC LNSRETSFIT NGSCLASRKT SFMMALCLSS IYEDLKMYQV EFKTMNAKLLMDPKRQIFLD QNMLAVIDEL MQALNFNSET VPQKSSLEEP DFYKTKIKLC ILLHAFRIRAVTIDRVMSYL NAS
• Sequence Similarities: Belongs to the IL-6 superfamily.

Gene Information

• Gene Name: IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) [ Homo sapiens ]
• Official Symbol: IL12A
• Synonyms: IL12A; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); NKSF1; interleukin-12 subunit alpha; CLMF; cytotoxic lymphocyte maturation factor 1; p35; IL 12; subunit p35; IL 12A; IL35 subunit; interleuk
• Gene ID: 3592
• mRNA Refseq: NM_000882
• Protein Refseq: NP_000873
• MIM: 161560
• Uniprot ID: P29459
• Chromosome Location: 3p12-q13.2
• Pathway: African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Amoebiasis, organism-specific biosystem
• Function: contributes_to cytokine activity; contributes_to cytokine activity; contributes_to growth factor activity; contributes_to growth factor activity; interleukin-12 beta subunit binding