Recombinant Human SIRT1
Cat.No. : | SIRT1-30565TH |
Product Overview : | Recombinant fragment: Human Sirtuin 1 , amino acids 193- 741,with an N-terminal enzyme tag. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. |
Source : | E. coli |
Tissue specificity : | Widely expressed. |
Biological activity : | Specific Activity: 8 U/ug. One Unit =1 pmol/min, Assay condition: 25 mM Tris/Cl, pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 uM BPS HDAC substrate, 200 uM NAD+ and 20 ng/ul Sirtuin 1. Incubation condition: 30 min at 30oC. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 0.05% Tween 20, 50mM Tris, 2.7mM Potassium chloride, 138mM Sodium chloride, pH 8.0 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain. |
Gene Name : | SIRT1 sirtuin 1 [ Homo sapiens ] |
Official Symbol : | SIRT1 |
Synonyms : | SIRT1; sirtuin 1; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1; NAD-dependent deacetylase sirtuin-1; SIR2L1; |
Gene ID : | 23411 |
mRNA Refseq : | NM_001142498 |
Protein Refseq : | NP_001135970 |
MIM : | 604479 |
Uniprot ID : | Q96EB6 |
Chromosome Location : | 10q21 |
Pathway : | E2F transcription factor network, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem; |
Function : | HLH domain binding; NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); |
Products Types
◆ Recombinant Protein | ||
SIRT1-100M | Recombinant Mouse SIRT1 Protein, His-tagged | +Inquiry |
SIRT1-30H | Recombinant Human SIRT1 Protein, GST-tagged | +Inquiry |
SIRT1-1165H | Recombinant Human SIRT1 protein(Met193-Ser747), His-tagged | +Inquiry |
Sirt1-2058R | Recombinant Rat Sirt1 Protein, His-tagged | +Inquiry |
SIRT1-113H | Recombinant Human SIRT1 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
SIRT1-595HCL | Recombinant Human SIRT1 lysate | +Inquiry |
◆ Assay kits | ||
Kit-2024 | SIRT1 Direct Fluorescent Screening Assay Kit | +Inquiry |
Kit-2156 | SIRT1 Inhibitor/Activator Screening Kit | +Inquiry |
Kit-2025 | SIRT1 FRET-Based Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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