Recombinant Mouse Tnfrsf10b
Cat.No. : | Tnfrsf10b-178M |
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Cat. No. : | Tnfrsf10b-178M |
Description : | Tumor necrosis factor-related apoptosis-inducing ligand Receptor 2 (TRAIL-R2) is a cell-surface receptor involved in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell-death signaling. The death ligand TRAIL bears high potential as a new anticancer agent, as binding to the death receptors TRAIL-R1 or TRAIL-R2 triggers apoptosis in most cancer cells. TRAIL-R2 has been shown to be associated with a decrease in the survival rates of breast cancer patients. |
Source : | Sf 21 Insect Cells. |
Molecular Weight : | The predicted molecular weight of Recombinant Mouse TRAIL R2 is Mr 40 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 49 kDa. |
State Of Matter : | Lyophilized. |
Purity : | >95% by SDS Page and analyzed by silver stain. |
Endotoxin : | <0.1 ng per 1 µg as determined by the LAL method. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b [ Mus musculus ] |
Synonyms : | Tnfrsf10b; tumor necrosis factor receptor superfamily, member 10b; MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B |
Gene ID : | 21933 |
mRNA Refseq : | NM_009379 |
Protein Refseq : | NP_033405 |
UniProt ID : | P40226 |
Chromosome Location : | 14 D2 |
Pathway : | Apoptosis; Cytokine-cytokine receptor interaction; Natural killer cell mediated cytotoxicity |
Function : | TRAIL binding; caspase activator activity; protein binding; receptor activity |
Products Types
◆ Recombinant Protein | ||
TNFRSF10B-463H | Recombinant Human TNFRSF10B Protein, Fc-tagged | +Inquiry |
TNFRSF10B-1999H | Recombinant Human TNFRSF10B Protein, MYC/DDK-tagged | +Inquiry |
TNFRSF10B-2136H | Recombinant Human TNFRSF10B Protein, His-tagged | +Inquiry |
Tnfrsf10b-6544M | Recombinant Mouse Tnfrsf10b Protein, Myc/DDK-tagged | +Inquiry |
TNFRSF10B-1148H | Recombinant Human TNFRSF10B Protein (Met1-Glu182), HlgG1 Fc-tagged | +Inquiry |
◆ Lysates | ||
TNFRSF10B-2397MCL | Recombinant Mouse TNFRSF10B cell lysate | +Inquiry |
TNFRSF10B-2829HCL | Recombinant Human TNFRSF10B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionActivation of TNFRSF10B triggers apoptotic pathways, leading to programmed cell death in cancer cells.
TNFRSF10B has been implicated in certain autoimmune diseases and neurodegenerative disorders, highlighting its diverse roles in various physiological processes.
TNFRSF10B expression levels may serve as a potential diagnostic marker for certain cancers, aiding in cancer detection and prognosis.
TNFRSF10B expression is often altered in various cancers, including breast cancer, colorectal cancer, and lung cancer.
Side effects may occur, and ongoing research aims to minimize these effects while maximizing the therapeutic benefits of targeting TNFRSF10B.
Customer Reviews (3)
Write a reviewThe combination of high-quality TNFRSF10B protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.
The manufacturer's extensive experience and expertise in the field of TNFRSF10B protein research make them a trusted partner.
The manufacturer's commitment to providing excellent technical support is highly valuable.
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