Recombinant Human SERPINA3

• Cat.No.: SERPINA3-487H
• Product Overview: Recombinant human alpha-1-antichymotrypsin protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 47.6 kDa (421aa).

Specification

• Cat. No.: SERPINA3-487H
• Description: Alpha-1-antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein"s sequence have been implicated in Alzheimer"s disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
• Source: E.coli.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MHPNSPLDEE NLTQENQDRG THVDLGLASA NVDFAFSLYK QLVLKAPDKN VIFSPLSIST ALAFLSLGAH NTTLTEILKG LKFNLTETSE AEIHQSFQHL LRTLNQSSDE LQLSMGNAMF VKEQLSLLDR FTEDAKRLYG SEAFATDFQD SAAAKKLIND YVKNGTRGKI TDLIKDLDSQ TMMVLVNYIF FKAKWEMPFD PQDTHQSRFY LSKKKWVMVP MMSLHHLTIP YFRDEELSCT VVELKYTGNA SALFILPDQD KMEEVEAMLL PETLKRWRDS LEFREIGELY LPKFSISRDY NLNDILLQLG IEEAFTSKAD LSGITGARNL AVSQVVHKAV LDVFEEGTEA SAATAVKITL LSALVETRTI VRFNRPFLMI IVPTDTQNIF FMSKVTNPKQ A
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 1mM DTT.
• Purity: > 95% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 [ Homo sapiens ]
• Synonyms: SERPINA3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; ACT; AACT; GIG24; GIG25; MGC88254; serpin peptidase inhibitor, clade A, member 3; alpha-1-antichymotrypsin; growth-inhibiting protein 24; growth-inhibiting protein 25; serine (or cysteine) proteinase inhibitor, clade A, member 3; Cell growth-inhibiting gene 24/25 protein; Alpha-1-antichymotrypsin His-Pro-less; antichymotrypsin
• Gene ID: 12
• mRNA Refseq: NM_001085
• Protein Refseq: NP_001076
• MIM: 107280
• UniProt ID: P01011
• Chromosome Location: 14q32.1
• Function: DNA binding; peptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity