Recombinant Human DEK, GST-tagged

• Cat.No.: DEK-2046H
• Product Overview: Recombinant human DEK protein with a GST tag produced in E. coli.

Specification

• Description: This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: GST
• Molecular Mass: ~ 70-kDa
• Purity: > 90% by SDS-PAGE
• Storage: Maintain preparations in aliquots at -70° C. Avoid repeated thawing.
• Storage Buffer: 1 μg in 50 μl 50 mM Tris-HCl pH 7.0 buffer containing 14 mM β-mercaptoethanol, 1 mM benzamidine, 0.1 mM phenylmethanesulfonyl fluoride, 1 mM EDTA and 10% glycerol.

Gene Information

• Gene Name: DEK DEK proto-oncogene [ Homo sapiens (human) ]
• Official Symbol: DEK
• Synonyms: DEK; D6S231E; DEK proto-oncogene; protein DEK; DEK oncogene (DNA binding)
• Gene ID: 7913
• mRNA Refseq: NM_001134709
• Protein Refseq: NP_001128181
• MIM: 125264
• UniProt ID: P35659
• Chromosome Location: 6p22.3
• Function: DNA binding; histone binding; poly(A) RNA binding