Recombinant Rat Ppp1r1b, Phosphorylated

• Cat.No.: Ppp1r1b-2634R
• Product Overview: Recombinant Rat Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B is expressed inE. coliand phosphorylated on Thr34 by cAMP-dependent protein kinase (PKA).

Specification

• Cat. No.: Ppp1r1b-2634R
• Description: Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons that also express dopamine D1 receptors.
• Source: E. coli.
• Form: White lyophilized solid.
• Molar Mass: 32000Da.
• Solubility: 50 mM Tris-HCl buffer, pH 7.0.
• Purity: ≥95% by SDS-PAGE.
• Storage: ≤ -20oC. Ship: Dry Ice Only.

Gene Information

• Gene Name: Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B [ Rattus norvegicus ]
• Synonyms:
  Ppp1r1b; protein phosphatase 1, regulatory (inhibitor) subunit 1B; dopamine- and cAMP-regulated neuronal phosphoprotein; dopamine- and cAMP-regulated phosphoprotein DARPP-32; neuronal phosphoprotein DARPP-32; protein phosphatase 1 regulatory subunit 1B; Darpp-32; Darpp32
• Gene ID: 360616
• mRNA Refseq: NM_138521
• Protein Refseq: NP_612530
• UniProt ID: Q6J4I0
• Chromosome Location: 10q31
• Function: phosphoprotein phosphatase inhibitor activity; receptor binding