Recombinant Human CDK1, GST-His

• Cat.No.: CDK1-2660H
• Product Overview: Recombinant Human CDK1 (amino acids M1 - M297) both N-terminally fused to GST-HIS6-Thrombin cleavage site is expressed inSf9 cells.

Specification

• Cat. No.: CDK1-2660H
• Description: CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes.
• Source: Sf9 cells.
• Concentration: 0.105 mg/ml.
• Molecular Weight: 77.1 kDa.
• Formulation: Liquid in 50 mM Tris-HCl, pH 8.0 + 100 mM NaCl + 5 mM DTT + 15 mM reduced glutathione + 20% glycerol.
• Specific Activity: 51 pmol/μg x min.

Gene Information

• Gene Name: CDK1 cyclin-dependent kinase 1 [ Homo sapiens ]
• Synonyms:
  CDK1; cyclin-dependent kinase 1; CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; cell division cycle 2; OTTHUMP00000019659; OTTHUMP00000019660; OTTHUMP00000019661; p34 protein kinase; cell cycle controller CDC2; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; EC 2.7.11.23; EC 2.7.11.22; CCNA2; cyclin A2; CCN1; CCNA; Cyclin-A; Cyclin-A2
• Gene ID: 983
• mRNA Refseq: NM_001170406
• Protein Refseq: NP_001163877
• MIM: 116940
• UniProt ID: P06493
• Chromosome Location: 10q21.1
• Pathway: Cell cycle; Gap junction; Progesterone-mediated oocyte maturation; p53 signaling pathway; Cell cycle; Progesterone-mediated oocyte maturation
• Function: ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; transferase activity; protein binding

Reviews

01/30/2023

The product brochure is very detailed and has comprehensive basic information about the CDK1 protein.

11/09/2022

The staff actively communicated with me and solved many technical problems.

10/18/2022

Very professional customer service, fully understanding the needs of the customer and giving professional advice.

Q&As

What diseases is CDK1 involved in?

CDK1 is involved in papillary thyroid cancer, hepatocellular carcinoma, and other diseases.

How does CDK1 relate to IL-33 expression?

CDK1 is positively correlated with IL⁃33 expression and CDK1 and IL⁃33 expression interact with each other.

What is the function of CDK1?

CDK1 is an important regulator of the eukaryotic cell cycle that drives cell cycle progression by binding to cell cycle proteins.

What is the expression level of CDK1 in colorectal cancer?

CDK1 expression levels were higher in CRC tissues than in paracancerous tissues.