Active GMP Recombinant Human BMP4 Protein

• Cat.No.: BMP4-135HG
• Product Overview: Recombinant Human BMP4, Ser293-Arg408, was produced in NS0 cell under cGMP guidelines.

Specification

• Source: Mammalian cells
• Species: Human
• Form: Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
• Bio-activity: Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem. Biophys. Res. Commun. 315(2):272.
• Molecular Mass: Predicted Molecular Mass: 13 (monomer) kDa
  SDS-PAGE: 22-25 kDa, reducing conditions; 37-41 kDa, non-reducing conditions
• N-terminal Sequence Analysis: Ser293-Pro-Lys-His-His-Ser-Gln-Arg-Ala-Arg
• Endotoxin: <0.01 EU per 1 μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE with silver staining, under reducing conditions.
• Storage: Avoid repeated freeze-thaw cycles.
  12 months, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 50-200 μg/mL in 4 mM HCl.
• Quality Statement: Our GMP proteins are produced according to relevant sections of the following documents: WHO TRS, No. 822, 1992 Annex 1, Good Manufacturing Practices for Biological Products; USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and USP Chapter 92, Growth Factors and Cytokines Used in Cell Therapy Manufacturing.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Gene Information

• Gene Name: BMP4 bone morphogenetic protein 4 [ Homo sapiens ]
• Official Symbol: BMP4
• Synonyms: BMP4; bone morphogenetic protein 4; BMP2B; BMP-4; BMP-2B; bone morphogenetic protein 2B; ZYME; OFC11; BMP2B1; MCOPS6
• Gene ID: 652
• mRNA Refseq: NM_001202
• Protein Refseq: NP_001193
• MIM: 112262
• UniProt ID: P12644

Reviews

11/22/2020

The BMP4 protein is a valuable resource for researchers due to its high quality and its ability to meet specific experimental needs.

08/26/2020

the manufacturer's technical support team can offer prompt assistance in case any issues arise during the handling or application of the BMP4 protein.

06/05/2018

The manufacturer's support can play a crucial role in assisting researchers throughout their trials.

Q&As

How is BMP4 applied in spinal fusion surgery?

BMP4 can be used in spinal fusion surgery to stimulate bone growth and fuse vertebrae together, which can alleviate back pain and stabilize the spine.

Are there any genetic disorders related to BMP4?

Mutations in BMP4 or its receptors can lead to congenital disorders, such as orofacial clefts and heart defects.

Are there ongoing clinical trials involving BMP4 in regenerative medicine?

Yes, there are ongoing trials exploring the use of BMP4 in regenerative medicine for conditions like osteoarthritis and tendon injuries.

Are there any potential risks or side effects associated with the clinical use of BMP4?

Yes, some risks include excessive bone growth, swelling, and inflammation at the application site. These complications can be carefully managed by healthcare providers.

Can BMP4 be used in cosmetic surgery?

Yes, BMP4 can be used to aid in tissue regeneration in cosmetic procedures, such as in the reconstruction of facial bone defects or enhancement of soft tissue volume.