Mouse Anti-Human ADAM Metallopeptidase Domain 12 Monoclonal Antibody

• Cat.No.: CABT-676MH
• Product Overview: Mouse Anti-Human ADAM metallopeptidase domain 12 Monoclonal Antibody.

Specification

• Cat. No.: CABT-676MH
• Antigen Dscription: This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis.
• Host Animal: Mouse
• Species Reactivity: Human
• Immunogen: A recombinant polypeptide corresponding to amino acids 208-305 of human ADAM12, expressed as a GST fusion protein.
• Clone: 2H4
• Isotype: IgG3
• Format: Purified
• Presentation: Liquid; In PBS, pH 7.2, containing no preservative.
• Applications: ELISA (this antibody can be used as the capture antibody; recommended concentration is 10 ng/ml, 1 μg/well, 100 μl total volume. Variables associated with assay conditions will dictate the proper working dilution); Immunoblotting (1-5 μg/ml).
• Storage: Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.
• Officialsymbol: ADAM12

Gene Information

• Gene Name: ADAM12 ADAM metallopeptidase domain 12 [ Homo sapiens ]
• Synonyms: ADAM12; ADAM metallopeptidase domain 12; MCMP; MCMPMltna; MLTN; MLTNA; A Disintegrin and Metalloprotease Domain 12 S isoform; ADAM12 precursor (EC 3.4.24); Meltrin alpha; ADAM12 ADAM metallopeptidase domain 12; OTTHUMP00000020727; OTTHUMP00000046766; a disintegrin and metalloproteinase domain 12 (meltrin alpha); EC 3.4.24.; A disintegrin and metalloproteinase domain 12
• Gene ID: 8038
• mRNA Refseq: NM_003474
• Protein Refseq: NP_003465
• MIM: 602714
• UniProt ID: O43184
• Chromosome Location: 10q26.3
• Pathway: Signaling by EGFR
• Function: SH3 domain binding; metal ion binding ; metalloendopeptidase activity; peptidase activity; protein binding; zinc ion binding

Reviews

08/22/2020

The technical staff evaluated my experimental process and results and made many constructive comments

05/28/2019

Protein products are put into experiments with good effect and reliable experimental results

Q&As

In addition to studies related to breast cancer, what other diseases is ADAD12 currently being used to study?

Currently, ADAM12 is also involved in the study of lung cancer and liver cancer.

Does ADAM12 affect Vimentin expression?

ADAM12 upregulates the expression of Vimentin.

Does ADAM12 interact with insulin-like growth factor-binding protein-3 (IGFBP)-3?

ADAM12 interacts with insulin-like growth factor binding protein(IGFBP)-3.

I want to buy ADAM12-related proteins, do you provide other proteins?

We offer myoferlin and Vimentin proteins in addition to ADAM12 proteins.

What protein does ADAM12 hydrolyze?

ADAM12 protein can hydrolyze Delta-like 1、Ephrin-A1, etc.

What are the two conformations of ADAM12?

The two conformations of ADAM are the membrane-penetrating full-length type (ADAM12-L) and the secretory type (ADAM12-S), respectively.