Mouse Anti-IL32 Monoclonal Antibody

• Cat.No.: DMABT-H19213
• Product Overview: Mouse Anti-IL32 Monoclonal Antibody

Specification

• Antigen Description: Interleukin 32 (IL-32),previously known as a transcript (NK4), is produced by mitogen-activated lymphocytes, by IFNgamma-activated epithelial cells or by IL-12 and IL-18-activated NK cells.Its expression is increased following activation of T-cells by mitogens or the activation of NK cells by IL-2.IL-32 activates NF-kappa -B and p38 MAPK cytokine signal pathways. It has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues. IL-32 exists in at least four differentially spliced isoforms (alpha, beta, gamma and delta)with predicted molecular weight: ~26 kD.IL-32alpha is the shortest and most abundant of four potential splice variants of the pro-inflammatory cytokine IL-32.Potential modifications include myristoylation and N-glycosylation. Transfected IL-32 alpha was more likely to be cell-associated as compared to IL-32beta, suggesting an intracellular function.
• Target: IL32
• Immunogen: Recombinant human IL-32 alpha
• Host: Mouse
• Isotype: IgG1, kappa
• species: Human
• Conjugation: Biotin
• Applications: ELISA,Flow Cyt,WB,IFA,IP
• Preparation: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
• Usage recommendation: Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA detection antibody, a concentration range of 0.2-1 μg/ml is recommended. To obtain a linear standard curve, serial dilutions of human IL-32 recombinant protein ranging from 2000 to26pg/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application
• Concentration: 0.5 mg/ml
• Storage: The antibody solution should be stored undiluted at 4 °C.Do not freeze.
• Size: 50 μg

Gene Information

• Gene Name: IL32 interleukin 32 [ Homo sapiens ]
• Official Symbol: IL32
• Synonyms: IL32; interleukin 32; interleukin-32; natural killer cell transcript 4; NK4; TAIF; TAIFb; TAIFd; interleukin-32 eta; interleukin-32 small; interleukin-32 theta; natural killer cells protein 4; tumor necrosis factor alpha-inducing factor; TAIFa; TAIFc; IL-32beta; IL-32alpha; IL-32delta; IL-32gamma
• Gene ID: 9235
• mRNA Refseq: NM_001012631
• Protein Refseq: NP_001012649
• MIM: 606001
• UniProt ID: P24001
• Chromosome Location: 16p13.3
• Function: cytokine activity

Reviews

12/13/2022

IL32 protein has a long shelf life, which facilitates the continuity of subsequent experiments.

05/20/2022

Consistent results can be obtained using IL32 experiments and experimental uncertainty can be reduced.

10/26/2019

The IL32 shows excellent stability and repeatability under specific experimental conditions.

Q&As

Can recombinant IL32 be used to treat autoimmune diseases?

At present, research is ongoing, and IL32 is considered to have the potential to treat autoimmune diseases, but further clinical validation is required.

What is IL32?

IL32, a protein of human origin, is an interferon-induced cytokine with a variety of biological functions.

What is the progress of IL32 in clinical trials?

IL32 is in clinical trials and will take time to evaluate its safety and efficacy.

Is recombinant IL32 associated with inflammation?

IL32 induce and regulate inflammatory response and participate in immune and inflammatory processes.

Can IL32 improve immunity?

Can enhance the activity and function of immune cells, thereby improving the body immunity.

What are the side effects of IL32?

So far, there have been no clear reports of side effects of IL32, but attention should be paid to reasonable dosage and method of use when using it.