Rat Anti-IL12B Monoclonal Antibody
Cat.No. : | DMABT-H19271 |
Product Overview : | Rat Anti-IL12B Monoclonal Antibody |
- Specification
- Gene Information
- Related Products
Antigen Description : | Bioactive IL-12 is a potent regulator of cell-mediated immune responses and key mediator of Th1 cell development. Bioactive IL-12 is secreted by activated B lymphocytes, dendritic cells and macrophages as a 70 kD heterodimeric glycoprotein comprised of disulfide-bonded 35 kD and 40 kD subunits. The disulfide-linked p40 homodimer can bind to IL-12 receptors and antagonize the activities of bioactive IL-12. |
Target : | IL12B |
Host : | Rat |
Isotype : | IgG1, kappa |
species : | Human |
Clone : | 8C23 |
Conjugation : | N/A |
Applications : | ELISA,ELISPOT |
Preparation : | The LEAF (Low Endotoxin, Azide-Free) antibody was Purified by affinity chromatography. |
Usage recommendation : | Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, a concentration range of 1-4 μg/ml is recommended. To obtain a linear standard curve, serial dilutions of IL-12 p70 recombinant protein ranging from 1000 to 8 pg/ml are recommended for each ELISA plate. For use as an ELISPOT capture antibody, a concentration range of 2-6 μg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application. |
Concentration : | 1.0 mg/ml |
Storage : | The antibody solution should be stored undiluted at 4 °C. This LEAF solution contains no preservative; handle under aseptic conditions. |
Size : | 500 μg |
Gene Name : | IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [ Homo sapiens ] |
Official Symbol : | IL12B |
Synonyms : | IL12B; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); NKSF2; interleukin-12 subunit beta; CLMF; CLMF2; cytotoxic lymphocyte maturation factor 2; p40; IL 12B; IL12; subunit p40; interleukin 12; interleukin 12 beta chain; natural killer cell stimulatory factor; 40 kD subunit; natural killer cell stimulatory factor 2; NKSF; CLMF p40; IL-12 subunit p40; IL12, subunit p40; interleukin 12, p40; interleukin-12 beta chain; NK cell stimulatory factor chain 2; cytotoxic lymphocyte maturation factor 40 kDa subunit; natural killer cell stimulatory factor, 40 kD subunit; IL-12B; |
Gene ID : | 3593 |
mRNA Refseq : | NM_002187 |
Protein Refseq : | NP_002178 |
MIM : | 161561 |
UniProt ID : | P29460 |
Chromosome Location : | 5q31.1-q33.1 |
Pathway : | African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; |
Function : | contributes_to cytokine activity; cytokine receptor activity; contributes_to growth factor activity; identical protein binding; interleukin-12 alpha subunit binding; interleukin-12 receptor binding; contributes_to interleukin-12 receptor binding; contributes_to interleukin-23 receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; |
Products Types
◆ Recombinant Protein | ||
IL12B-576S | Recombinant Sheep IL12B Protein (23-327 aa), His-tagged | +Inquiry |
IL12B-3C | Recombinant Canine IL12B Protein, His (Fc)-Avi-tagged | +Inquiry |
Il12b-142M | Recombinant Active Mouse IL12B Protein, His-tagged(C-ter) | +Inquiry |
IL12B-4330S | Recombinant Sheep IL12B Protein | +Inquiry |
IL12B-503H | Recombinant Human IL12B Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
IL12B-1101MCL | Recombinant Mouse IL12B cell lysate | +Inquiry |
IL12B-1197RCL | Recombinant Rat IL12B cell lysate | +Inquiry |
IL12B-2731HCL | Recombinant Human IL12B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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