Recombinant Active Human CDK12/Cyclin K Complex Protein, GST-tagged
Cat.No. : | CDK12-07H |
Product Overview : | Recombinant human CDK12 (658-end) /Cyclin K complex was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins. |
- Specification
- Gene Information
- Related Products
Description : | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. |
Source : | Insect cell |
Species : | Human |
Tag : | GST |
Molecular Mass : | CDK12: Approx 135 kDa CyclinK: Approx 67 kDa |
Purity : | > 85% |
Stability : | One year at -70 centigrade from data of shipment. |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.05 μg/μL |
Storage Buffer : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 25% glycerol. |
Shipping : | Dry ice |
Gene Name : | CDK12 cyclin dependent kinase 12 [ Homo sapiens (human) ] |
Official Symbol : | CDK12 |
Synonyms : | CDK12; cyclin dependent kinase 12; cyclin-dependent kinase 12; CDC2-related protein kinase 7; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7; cell division protein kinase 12; EC 2.7.11.22; EC 2.7.11.23 |
Gene ID : | 51755 |
mRNA Refseq : | NM_015083 |
Protein Refseq : | NP_055898 |
MIM : | 615514 |
UniProt ID : | Q9NYV4 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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