Recombinant Cynomolgus IL1RL1 protein (Met1-Cys331), His-tagged

• Cat.No.: IL1RL1-25C
• Product Overview: Recombinant cynomolgus IL1RL1 (XP_005575214.1) (Met1-Cys331) protein, fused with a polyhistidine tag at the C-terminus, was expressed in E. coli.

Specification

• CommonName: IL1RL1
• Source: HEK293
• Species: Cynomolgus
• Tag: His
• Predicted N Terminal: Ala 18
• Form: Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5% mannitol and 0.01% Tween80.
• Molecular Mass: The recombinant cynomolgus IL1RL1 consists of 325 amino acids and predicts a molecular mass of 37.1 kDa.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: > 95 % as determined by SDS-PAGE.
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Official Symbol: IL1RL1
• Synonyms: IL1RL1

Gene Information

• Official Symbol: IL1RL1
• Synonyms: IL1RL1

Reviews

07/25/2019

High specificity in ELISA.

01/30/2017

Suitable for flow cytometry.

07/13/2016

Effective in allergy models.

Q&As

Are there any splice variants of IL1RL1?

IL1RL1 has multiple splice variants that differ in signaling capabilities.

What is the role of IL1RL1 in allergic responses?

IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

Does IL1RL1 have a role in autoimmune diseases?

IL1RL1 is implicated in rheumatoid arthritis.

How does IL1RL1 affect cytokine production?

IL1RL1 increases the production of IL-4 and IL-13.

What is the subcellular localization of IL1RL1?

IL1RL1 is primarily membrane-bound.

Does IL1RL1 influence T-cell differentiation?

IL1RL1 promotes Th2 cell differentiation.

How does IL1RL1 interact with its ligands?

IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

Is IL1RL1 expression altered in any cancers?

IL1RL1 expression is altered in lung and breast cancer.

What post-translational modifications occur on IL1RL1?

IL1RL1 undergoes glycosylation and phosphorylation.

How is IL1RL1 expression regulated in asthmatic conditions?

IL1RL1 expression is upregulated in asthmatic conditions.