Recombinant Cynomolgus MICA protein(Glu1-Pro288), His-tagged

• Cat.No.: MICA-401C
• Product Overview: Recombinant Cynomolgus MICA (AAO24115.1) (Glu1-Pro288) was expressed in HEK293 with a polyhistidine tag at the C-terminus.

Specification

• Source: HEK293
• Species: Cynomolgus
• Tag: C-His
• Protein length: Glu1-Pro288
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant cynomolgus MICA consists of 299 amino acids and predicts a molecular mass of 34.3 kDa.
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Reviews

01/16/2022

when utilized in Western Blotting experiments, the MICA protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.

01/18/2020

I have successfully implemented the MICA protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.

03/23/2016

Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the MICA protein in various research studies.

Q&As

How does MICA relate to infectious diseases?

MICA expression can change during viral infections and influence the immune response to the pathogen.

How can MICA protein be targeted in cancer therapy?

Monoclonal antibodies and immunotherapies can target MICA on cancer cells, making them more susceptible to immune system attack.

Are there diagnostic tests that measure MICA expression in cancer patients?

Yes, tests like immunohistochemistry and flow cytometry can measure MICA expression on tumor cells and help in cancer diagnosis and treatment planning.

What are the implications of MICA expression in autoimmune diseases?

Altered MICA expression has been associated with some autoimmune diseases, such as rheumatoid arthritis, suggesting a potential role in disease development.

Can MICA polymorphisms affect the outcome of organ transplantation?

Yes, MICA polymorphisms can influence the success of organ transplantation by affecting the compatibility between donor and recipient.