Recombinant Cynomolgus Monkey ABHD16A Protein Pre-coupled Magnetic Beads
Cat.No. : | ABHD16A-13C-B |
Product Overview : | The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations. |
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Source : | HEK293 |
Species : | Cynomolgus Monkey |
Form : | Solution |
Particle size : | ~2 μm |
Beads Surface : | Hydrophilic |
Capacity : | > 200 pmol rabbit IgG/ mg beads |
Applications : | Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification. |
Stability : | Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. |
Storage : | 2-8℃. Do not to freeze thaw the Beads |
Concentration : | 10mg beads/mL |
Storage Buffer : | PBS buffer |
Gene Name : | ABHD16A Abhydrolase domain-containing protein 16A [ Macaca fascicularis (crab-eating macaque) ] |
Official Symbol : | ABHD16A |
Synonyms : | ABHD16A; BAT5; HLA-B-associated transcript 5; |
Gene ID : | 101866118 |
mRNA Refseq : | NM_001284096 |
Protein Refseq : | NP_001271025 |
UniProt ID : | Q4R8P0 |
Products Types
◆ Recombinant Protein | ||
ABHD16A-76R | Recombinant Rat ABHD16A Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD16A-13C | Recombinant Cynomolgus Monkey ABHD16A Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD16A-214M | Recombinant Mouse ABHD16A Protein, His (Fc)-Avi-tagged | +Inquiry |
ABHD16A-6239Z | Recombinant Zebrafish ABHD16A | +Inquiry |
ABHD16A-10144H | Recombinant Human ABHD1, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionUsing STED microscopy, we can found that mammalian ABHD12 is enriched at the ER membrane30, then checked for the co-localization of ABHD16A with ABHD12. Indeed, we found in Neuro-2a cells, that ABHD16A co-localizes with ABHD12, further confirming that ABHD16A is enriched at the ER membrane.
A complicated hereditary spastic paraplegia (HSP) caused by ABHD16A loss of function pathogenic variants and the subsequent altered phosphatidylserine (PS) metabolism.
The protein deglycosylation studies and the detergent-independent sensitivity of ABHD16A to proteolytic degradation, have suggested this point.
Inhibited by beta-lactone-based lipid inhibitors, such as beta-lactone palmostatin-B
They are DTX2, RNF5, AGPAT3, TMEM147, and FAM134C.
ABHD16A is a 21-exon gene which encodes for the α/β hydrolase domain-containing 16A (ABHD16A) enzyme, which is the main brain phosphatidylserine (PS) hydrolase.
ABHD16A and ABHD12, are the main enzymes responsible for the brain LPS metabolism, as ABHD16A generates LPS while ABHD12 catabolizes them into fatty acid and phosphoserine.
ABHD16A PS lipase deficiency results in intellectual disability, progressive spasticity, abnormal corpus callosum, and white matter anomalies, most likely through the dysregulation of lipid species including lyso-PS.
We found relative to the tubulin protein loading control, that ABHD16A was maximally enriched in the cerebellum, and the olfactory bulb, while ABHD12 is ubiquitously expressed at near equal levels in all the aforementioned brain regions.
ABHD16A has a heterogeneous expression in the murine brain and is enriched in the cerebellum, particularly in the granular layer and the olfactory bulb.
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