Recombinant Dog MSTN protein(267-375aa), His-tagged

• Cat.No.: MSTN-224D
• Product Overview: Recombinant Dog MSTN protein(Q6UKZ8)(267-375aa), fused with N-terminal His tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Dog
• Tag: N-His
• Protein length: 267-375aa
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 16.5 kDa
• AASequence: DFGLDCDEHSTESRCCRYPLTVDFE AFGWDWIIAPKRYKANYCSGECEFV FLQKYPHTHLVHQANPRGSAGPCCT PTKMSPINMLYFNGKEQIIYGKIPA MVVDRCGCS
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Gene Information

• Gene Name: MSTN myostatin [ Canis lupus familiaris ]
• Official Symbol: MSTN
• Synonyms: MSTN; myostatin; growth/differentiation factor 8; GDF-8; growth differentiation factor 8; GDF8
• Gene ID: 403433
• mRNA Refseq: NM_001002959
• Protein Refseq: NP_001002959

Reviews

04/04/2021

The MSTN protein surpasses expectations in terms of quality and will undoubtedly fulfill my experimental requirements.

11/15/2020

the manufacturer of MSTN provides exceptional technical support, offering valuable assistance in troubleshooting and experimental design.

02/01/2020

The outstanding level of customer service adds extra reassurance and confidence in using the MSTN protein for my scientific investigations.

Q&As

How do MSTN inhibitors work in the context of muscle-related disorders?

MSTN inhibitors work by blocking the activity of the MSTN protein, thus promoting muscle growth and potentially reversing muscle loss.

Are there any known side effects of using MSTN inhibitors in clinical trials?

Some potential side effects include joint stiffness, increased risk of fractures, and insulin resistance, which require close monitoring during trials.

How does the overexpression of MSTN affect muscle development?

Overexpression of MSTN can lead to muscle atrophy and decreased muscle mass.

How do researchers regulate the dosage of MSTN protein therapy to ensure safety and efficacy?

Researchers carefully monitor the dosage and administration of MSTN protein therapy through preclinical and clinical studies to establish the optimal therapeutic dose.

What are the potential risks associated with MSTN protein therapy?

Possible risks include unintended effects on other organ systems and potential complications related to excessive muscle growth.