Recombinant Equine Interleukin 17A

• Cat.No.: IL17A-254E
• Product Overview: Recombinant Equine IL-17A was expressed inYeast. MW= 14.9 kDa (130 aa).

Specification

• Cat. No.: IL17A-254E
• Description: Interleukin-17A is a protein that in humans is encoded by the IL17A gene. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
• Source: Yeast.
• Formulation/ Reconstitution: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
• Purification: Ion-exchange chromatography.
• Purity: >95% as visualized by SDS-PAGE analysis.
• Amino Acid Sequence: GIVIPQNPEC PNTGDKNFPQ NVKINLNVLN RKTNSRRASD YHNRSTSPWN LHRNEDPERY PSVIWEAKCR HLGCVNAEGK VDFHMNSVPI QQEILVLRRE SQNCPHSFQL EKMLVAVGCT CVTPIVRHMG.
• Bioactivity: In testing.
• Stability And Storage: Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.

Gene Information

• Gene Name: IL17A interleukin 17A [ Equus caballus ]
• Synonyms: interleukin 17A; IL17A; IL17; interleukin 17
• Gene ID: 100034142
• mRNA Refseq: NM_001143792.1
• Protein Refseq: NP_001137264.1
• Chromosome Location: 20
• Pathway: Cytokine-cytokine receptor interaction