Recombinant Full Length Bovine Type-1 Angiotensin Ii Receptor(Agtr1) Protein, His-Tagged

• Cat.No.: RFL-20399BF
• Product Overview: Recombinant Full Length Bovine Type-1 angiotensin II receptor(AGTR1) Protein (P25104) (1-359aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Bos taurus (Bovine)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length (1-359)
• AA Sequence: MILNSSTEDGIKRIQDDCPKAGRHN YIFIMIPTLYSIIFVVGIFGNSLVV IVIYFYMKLK TVASVFLLNLALADLCFLLTLPLWA VYTAMEYRWPFGNYLCKIASASVSF NLYASVFLLT CLSIDRYLAIVHPMKSRLRRTMLVA KVTCIIIWLLAGLASLPTIIHRNVF FIENTNITVC AFHYESQNSTLPVGLGLTKNILGFL FPFLIILTSYTLIWKTLKKAYEIQK NKPRKDDIFK IILAIVLFFFFSWVPHQIFTFMDVL IQLGLIRDCKIEDIVDTAMPITICL AYFNNCLNPL FYGFLGKKFKKYFLQLLKYIPPKAK SHSNLSTKMSTLSYRPSENGNSSTK KPAPCIEVE
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: AGTR1
• Synonyms: AGTR1; Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; AT1
• UniProt ID: P25104

Gene Information

• Gene Name: AGTR1
• Synonyms: AGTR1; Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; AT1
• UniProt ID: P25104

Reviews

09/28/2022

It's like a ray of sunshine in our experiments, bringing joy and reliable data. A true delight to work with!

09/02/2022

I have been a loyal customer of this supplier for years due to their commitment to delivering proteins of exceptional quality at competitive prices.

01/19/2021

The post-sale services provided detailed technical support and ensured that I had a positive experience with their products.

03/15/2020

Love the affordable price and great quality of the recombinant proteins I purchased!

Q&As

How is AGTR1 involved in the regulation of renal function?

AGTR1 activation in the kidneys leads to vasoconstriction of renal blood vessels, increased sodium reabsorption, and stimulation of aldosterone release, ultimately impacting renal function.

How does AGTR1 contribute to hypertension?

Overactivation of AGTR1 can lead to increased vasoconstriction, sodium retention, and stimulation of aldosterone release, all of which contribute to hypertension.

What are the tissue distribution and expression of AGTR1?

AGTR1 is widely expressed throughout the body, with high levels found in the cardiovascular system, kidneys, and adrenal glands.

Are there genetic variations in AGTR1 associated with disease susceptibility?

Yes, genetic variations in the AGTR1 gene have been associated with increased susceptibility to cardiovascular diseases, hypertension, and other conditions influenced by the renin-angiotensin system.

Can AGTR1 influence inflammatory processes?

AGTR1 activation can modulate inflammatory responses, contributing to inflammation-associated conditions such as atherosclerosis and chronic kidney disease.

How does AGTR1 signal within cells?

Upon angiotensin II binding, AGTR1 activates intracellular signaling pathways, such as G-protein-mediated pathways and the activation of downstream kinases.

How does AGTR1 affect angiogenesis?

AGTR1 activation can promote angiogenesis, the formation of new blood vessels, by stimulating endothelial cell proliferation and migration.

What are the downstream signaling pathways activated by AGTR1?

AGTR1 can activate pathways such as the phosphoinositide 3-kinase (PI3K)/Akt pathway, mitogen-activated protein kinase (MAPK) pathway, and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway.

Can AGTR1 be involved in cancer progression?

AGTR1 has been implicated in cancer development and progression due to its role in cellular growth, angiogenesis, and inflammation.

How does AGTR1 contribute to oxidative stress?

AGTR1 activation can promote the generation of reactive oxygen species, contributing to oxidative stress and cellular damage.